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Faculty Profile

hu-chenlin.jpgChenlin Hu

Research Scientist
Department of Pharmacy Practice and Translational Research

University of Houston College of Pharmacy
Health 2, Room 4040
4349 Martin Luther King Boulevard
Houston, TX 77204-5039


Research/Academic Interests:

My research develops cutting-edge knowledge and technologies to address these urgent problems in public health microbiology with focus on freshwater harmful algal blooms and clinical multidrug resistance. My research on freshwater harmful algal blooms focuses on the cause and control of harmful algal blooms, evaluation and management of algal toxin risks, analysis of algal toxin and algal bioactive, UV-absorbing compound mycosporine-like amino acid. My present research on clinical multidrug resistance focuses on developing cutting-edge technologies for pharmaceutical and metabolite detection, advanced cell imaging, gene editing to advance the development of new drugs.

  • Ph.D. in Environmental Science, Chinese Academy of Sciences
  • Bsc., Applied Chemistry, Wuhan University

ORCID Profile
Google Scholar Profile

  • Mason CS, Avis T, Hu C, Nagalingam N, Mudaliar M, Coward C, Begum K, Gajewski K, Alam MJ, Bassères E, Moss S, Reich S, Duperchy E, Fox KR, Garey KW, and Powell DJ. The novel DNA binding mechanism of ridinilazole, a precision Clostridiodes difficile antibiotic. Antimicrob Agents Chemother. 2023 Apr 24; e0156322. (DOI: 10.1128/aac.01563-22)
  • Hu C, Garey KW. Nonmammalian models to study Clostridioides difficile infection; a systematic review. Anaerobe, 2023 (79) 102694 (DOI: 10.1016/j.anaerobe.2023.102694)
  • Hu C, Wang W, Garey KW. Heterogeneity and lyophilization comparison of stool processing for gastrointestinal bile acid measurement by LC-MS/MS. J Chromatogr B, 2023(1214), 123569 (DOI:
  • McPherson J, Hu C, Begum K, Wang W, Lancaster C, Gonzales-Luna A, Loveall C, Silverman MH, Alam MJ, and Garey KW. Functional and Metagenomic Evaluation of Ibezapolstat for Early Evaluation of Anti-Recurrence Effects in Clostridioides difficile Infection. Antimicrob Agents Chemother. 2022. (DOI:
  • Hu C, Byeda N, and Garey K. A Vancomycin HPLC Assay for Use in Gut Microbiome Research, Microbiology Spectrum, 2022,10(3):e0168821 (DOI:10.1128/spectrum.01688-21)
  • Hu C and Rzymski P. Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut: Characteristics and Association with Health. Life, 2022, 12(4) 476. (DOI: 10.3390/life12040476)
  • Garey KW, McPherson J, Dinh AQ, Hu C, Jo J, et al. Efficacy, Safety, Pharmacokinetics, and Microbiome Changes of Ibezapolstat in Adults with Clostridioides difficile Infection: A Phase 2a Multicenter Clinical Trial. Clin Infect Dis, 2022 (DOI: 10.1093/cid/ciac096)
  • Hu C, Fong G. Wurster ST, Kontoyiannis D, Beyda NBD. Clumping morphology influences virulence
    uncoupled from echinocandin resistance in Candida glabrata. Microbilogy Spectrum 2022, 10 (1) e01837-21. (DOI: 10.1128/spectrum.01837-21)
  • Hu C, Zuo Y, Peng L, Gan N, Song L.. Widespread Distribution and Adaptive Degradation of Microcystin Degrader (mlr-Genotype) in Lake Taihu, China. Toxins, 2021, 13:864. (DOI: 10.3390/toxins13120864)
  • Hu C and Rzymski P. Programmed Cell Death-Like and Accompanying Release of Microcystin in Freshwater Bloom-Forming Cyanobacterium Microcystis: From Identification to Ecological Relevance. Toxins, 2019, 11:706. (DOI: 10.3390/toxins11120706)
  • Hendrickson JA, Hu C, Aitken SL, Beyda N. Antifungal Resistance: a Concerning Trend for the Present and Future. Current Infectious Disease Reports, 2019, 21: 47. (DOI: 10.1007/s11908-019-0702-9)
  • Hu C and Lee J. A Novel Proof-of-Concept Sandwich Immunoassay for Screening Microcystin in Cyanobacteria based on Michael Addition Reaction. Anal Sci 2019, 35:107-111. (DOI: 10.2116/analsci.18SDN03)
  • Hu C, Ludsin SA, Martin JF, Dittmann E, Lee J. Mycosporine-like amino acids (MAAs)-producing Microcystis in Lake Erie: Development of a qPCR assay and insight into its ecology. Harmful Algae. 2018, 77: 1-10. (DOI: 10.1016/j.hal.2018.05.010)
  • Wituszynski DM, Hu C, Zhang F, Chaffin JD, Lee J, Ludsin SA, Martin JF. Microcystin in Lake Erie fish: Risk to human health and relationship to cyanobacterial blooms. J Great Lake Res 2017, 43:1084-1090. (DOI: 10.1016/j.jglr.2017.08.006 )
  • Hu C, Rea C, Yu Z, Lee J. Relative importance of Microcystis abundance and diversity in determining
    microcystin dynamics in Lake Erie coastal wetland and downstream beach water. J Appl Microbiol 2016, 120:138-151. (DOI: 10.1111/jam.12983)
  • Hu C, Voeller G, Suessmuth R, Dittmann E, Kehr J.C. Functional assessment of mycosporine-like amino acids in Microcystis aeruginosa strain PCC 7806. Environ Microbiol 2015, 17: 1548-1559. (DOI: 10.1111/1462-2920.12577)
  • Gan N, Xiao Y, Zhu L, Wu Z, Liu J, Hu C, Song L. The role of microcystins in maintaining colonies of bloom-forming Microcystis spp. Environ Microbiol 2012, 14: 730-742. (DOI: 10.1111/j.1462-2920.2011.02624.x)
  • Hu C, Gan N, Chen Y, Bi L, Zhang X, Song L. Detection of microcystins in environmental samples using surface plasmon resonance biosensor. Talanta 2009, 80: 407-410. (DOI: 10.1016/j.talanta.2009.06.044)
  • Hu C, Gan N, He Z, Song L. A novel chemiluminescent immunoassay for microcystin (MC) detection based on gold nanoparticles label and its application to MC analysis in aquatic environmental samples. Int J Environ Anal Chem 2008, 88: 267-277. (DOI: 10.1080/03067310701657543)

Awards & Honors

  • Best Postdoc Poster Presentation Award (second place, University of Houston) (2018)
  • DAAD (German Academic Exchange Service)-CSC (China Scholarship Council) scholarship for Joint
    Ph.D. training and education program (2009-2011)
  • Outstanding Graduate, Institute of Hydrobiology, Chinese Academy of Sciences (2008)
  • Outstanding Undergraduate, Wuhan University, China (2004)