Associate Professor of Pharmaceutics
University of Houston College of Pharmacy
4849 Calhoun Road, Room 7045
Houston, TX 77204-5037
MSc. (Biochemistry), University of Calcutta, India
Ph.D. (Biochemistry), University of Notre Dame, Notre Dame, IN
Post-doctoral, Baylor College of Medicine, Houston, TX
The primary research interest of our group is to investigate the regulation of drug metabolism and toxicity. The overall goal is to understand how drugs become less effective or more toxic in patients undergoing treatment for diseases such as infections, diabetes, cardiovascular diseases, cancer and liver disorders. The knowledge gained from these studies will have significant impact on developing novel strategies to reduce adverse effects of drugs and help us develop individualized approaches to treat patients.
Specific projects involve:
- Hepatic drug metabolism and transport
- Cytochrome P450 enzymes
- Nuclear receptors
- Drug-drug interactions
- Drug-induced liver injury
- Advanced Pharmaceutics I, PCEU 6342
- Cellular Pharmacology I, PCOL 7350
- Regulatory Affairs, PCEU 6346
- Laboratory Methods for Pharmaceutical Research, PCEU 7351
- Pharmaceutics I, PHAR 4330
- Pharmaceutics II, PHAR 4331
- Pharmacokinetics, PHAR 5332
- National Institutes of Health: K01, R21
- Northarvest Bean Growers Association
- Inflammation Research Foundation/Zone Labs
- National Institute of Diabetes and Digestive and Kidney Diseases
- University of Houston: Small Grants Program; GEAR Grant
- Pilot/Feasibility Award in GI Research. Texas Gulf Coast Digestive Diseases Center
Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose R. Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Expert Opin Drug Metab Toxicol. 2020 Nov;16(11):1109-1124. doi: 10.1080/17425255.2020.1815705. Epub 2020 Sep 2.
Sun R, Zhu L, Li L, Song W, Gong X, Qi X, Wang Y, Ghose R, Gao S, Hu M, Liu Z. Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt. Toxicol Appl Pharmacol. 2020 Jul 1;398:115032. doi: 10.1016/j.taap.2020.115032. Epub 2020 May 5.
Chityala PK, Wu L, Chow DS, Ghose R. Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model. Chem Biol Interact. 2020 Jan 25;316:108933. doi: 10.1016/j.cbi.2019.108933. Epub 2019 Dec 20.
Sun R, Basu S, Zeng M, Sunsong R, Li L, Ghose R, Wang W, Liu Z, Hu M, Gao S. Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Curr Cancer Drug Targets. 2019;19(7):551-560. doi: 10.2174/1568009618666181029153255.
Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose R. Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 Apr 30;9(1):6663. doi: 10.1038/s41598-019-43248-w.
Paranjpe R, Basatneh D, Tao G, De Angelis C, Noormohammed S, Ekinci E, Abughosh S, Ghose R, Trivedi MV. Neratinib in HER2-Positive Breast Cancer Patients. Ann Pharmacother. 2019 Jun;53(6):612-620. doi: 10.1177/1060028018824088. Epub 2019 Jan 4.
Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose R. Impact of diet on irinotecan toxicity in mice. Chem Biol Interact. 2018 Aug 1;291:87-94. doi: 10.1016/j.cbi.2018.06.018. Epub 2018 Jun 18.
Taneja G, Chu C, Maturu P, Moorthy B, Ghose R. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro. Drug Metab Dispos. 2018 Apr;46(4):397-404. doi: 10.1124/dmd.117.079160. Epub 2018 Feb 12.
Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BS. Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opin Drug Metab Toxicol. 2017 Sep;13(9):901-923. doi: 10.1080/17425255.2017.1360277. Epub 2017 Aug 17. Review. PMID:28766962
Mallick P, Taneja G, Moorthy B, Ghose R. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun;13(6):605-616. doi: 10.1080/17425255.2017.1292251. Epub 2017 Feb 22. Review. PMID: 28537216
Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun;41:75-82. doi: 10.1016/j.tiv.2017.02.019. Epub 2017 Feb 27. PMID: 28242239
Ghose R, Mallick P, Taneja G, Chu C, Moorthy B. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016;1395:55-68. doi: 10.1007/978-1-4939-3347-1_4. PMID: 26910068
Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon β in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan;44(1):61-7. doi: 10.1124/dmd.115.066761. Epub 2015 Oct 15. PMID: 26470915
Mallick P, Shah P, Gandhi A and Ghose R. Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38. Life Sci. 2015; Oct; 139: 132-138.
Pranav Shah, Tao Guo, David D Moore and Romi Ghose. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug metabolizing enzymes and transporters. Drug Met. Disp. 2014 Jan; 42 (1): 172-81.
Gandhi A, Guo T,Moorthy B and Ghose R. Chlorpromazine-induced hepatotoxicity in inflammationis mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol. 2013 Feb 1; 266 (3): 430-8.
Fahy BN, Guo T and Ghose R. Impact of Hepatic Malignancy on CYP3A4 Gene Expression. Journal of Surgical Research. 2012; Dec 178 (2): 768-72.
Gandhi A, Moorthy B and Ghose R. Drug Disposition in Pathophysiological Conditions. Current Drug metabolism. (Review) 2012 Nov; 13(9): 1327-44.
Gandhi A, Shah P, Guo T, Moorthy B, Chow S-L. D, Hu M & Ghose R. Altered pharmacokinetics and pharmacodynamicsof the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins.British Journal of Pharmacology. 2012; Aug 166 (7) : 2167-87.
Ghose R, Omoluabi O, Gandhi A, Shah P,Strohacker K, Carpenter KC, McFarlin B, Guo T. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011; Jul 4;89 (1-2):57-64.
Ghose R, Guo T, Vallejo S, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug metabolizing enzymes. Drug Met. Disp. 2011; 39 (5): 874-81.
Adarsh Gandhi, Tao Guo and Romi Ghose. Role of c-jun N-terminal kinase in regulating tumor necrosis factor-alpha mediated increase of acetaminophen and chlorpromazine toxicity in murine hepatocytes. J. Toxicol. Sci. 2010, 35; 163-73.
Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch. Biochem. Biophys. 2009, 481 (1): 123-30.
Ghose R, White D, Guo T, Vallejo S, Karpen SJ. Regulation of hepatic drug metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of TIR-domain containing adaptor protein (TIRAP). Drug Met. Disp. 36 (1): 95-101; 2008.
Ghose, R., J. Mulder and S. J. Karpen. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPARϒ agonist, Rosiglitazone. J Hepatol. 2007 46 (1): 115-123.
Gandhi A and Ghose R. Altered Drug Metabolism and Transport in Pathophysiological Conditions. 2012; Drug Metabolism. InTech - Open Access Publisher, ISBN 979-953-307-295-0.
Romi Ghose, Pankajini Mallick, Guncha Taneja, Chun Chu and Bhagavatula Moorthy. In vitro approaches to study regulation of hepatic cytochrome P450 (CYP) 3A expression by paclitaxel and rifampicin. 2015 Methods in Molecular Biology (In press).
- American Association for the Study of Liver Diseases
- American Society for Pharmacology and Experimental Therapeutics
- International Society for the Study of Xenobiotics
- Society of Toxicology
- Member of the Editorial Board: Chemico-Biological Interactions
- Member of the Editorial Board: Journal of Clinical Trials
- Member of the Editorial Board: Journal of Molecular Pharmaceutics and Organic Process Research