Faculty Profile
Alexander V. Statsyuk
Assistant Professor of Medicinal Chemistry
Department of Pharmacological and Pharmaceutical Sciences
Office:
University of Houston College of Pharmacy
Health 2, Room 7037
4349 Martin Luther King Boulevard
Houston, TX 77204-5039
Contact: avstatsyuk@uh.edu - Office: 713-743-9616 - Fax: 713-743-1884
Research:
Our research group is pursuing three related research directions:
- Biochemistry and pharmacology of the ubiquitin proteasome system.
- Bone biology.
- Drug discovery.
To pursue these research directions we use variety of interdisciplinary techniques, but chemistry constitutes the core of all of our research programs.
- Ph.D. in Organic Chemistry, University of Chicago, Chicago, Illinois
- Diploma in Chemistry, Lomonosov Moscow State University, Moscow, Russia
Google Scholar Profile
- Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites, Michael D. Olp, Daniel J. Sprague, Christopher J. Goetz, Stefan G. Kathman, Sarah L. Wynia-Smith, Shifali Shishodia, Steven B. Summers, Ziyang Xu, Alexander V. Statsyuk, Brian C. Smith, ACS Chemical Biology, 2020, 15(4):1036-1049
- LiF-MS: Mapping unstructured peptide-protein interactions using Ligand-Footprinting Mass Spectrometry, Parker, B.; Goncz, E.; Krist, D.T.; Statsyuk, A.V.; Nesvizhskii, A.I.; Weiss, E. Proceedings of the National Academy of Sciences, 2019, 116 (42): 21001-21011.
- UbMES and UbFluor: Novel Probes For RBR E3 Ubiquitin Ligase PARKIN. Park, S.; Foote, P.K.; Krist, D.T.; Rice, S.E.; Statsyuk, A.V. Journal of Biological Chemistry 2017, 292 (40):16539-16553.
- Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Misra, M.; Kuhn, M.; Löbel, M.; An, H.; Statsyuk, A.V.; Sotriffer, C.; Schindelin, H. Structure 2017, 25(7):1120-1129.e3.
- UbFluor: A Mechanism-Based Probe for HECT E3 Ligases. Krist, D.T.; Park, S.; Boneh, G.; Rice, S.; Statsyuk, A.V. Chemical Science 2016, 7, 5587-5595.
- A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. Kathman S.G.; Span I.; Smith A.T.; Xu, Z.Y.; Zhan J.; Rosenzweig A.C.; Statsyuk, A.V. Journal of the American Chemical Society 2015, 137 (39):12442-12445.
- Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-cross-linkers. Krist, D.T.; Statsyuk A.V. Biochemistry 2015, 54 (29), 4411-4414.
- A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases. Kathman, S.G.; Xu, Z.Y.; Statsyuk, A.V. Journal of Medicinal Chemistry 2014, 57 (11), 4969-74.
- Development of Activity-Based Probes for Ubiquitin and Ubiquitin-Like Protein Signaling Pathways. An, H.; Statsyuk A.V. Journal of the American Chemical Society 2013, 135 (45), 16948-16962.
- Mechanism-Based Small Molecule Cross-Linkers of HECT E3 Ubiquitin-Ligase Substrate Pairs. Park, S.; Ntai, I.; Thomas, P.; Konishcheva, E.; Kelleher, N.L.; Statsuk, A.V. Biochemistry 2012, 51(42), 8327-8329.
Awards & Honors
- Pew Scholar in the Biomedical Sciences (2012)