Skip to main content

Faculty Profile

Richard BondRichard A. Bond

Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences

University of Houston College of Pharmacy
Health 2, Room 5015
4349 Martin Luther King Boulevard
Houston, TX 77204-5037

Contact: - Office: 713-743-1210 - Fax: 713-743-1884


Our laboratory is interested in discovering or identifying better drugs for asthma, specifically:

  • Receptor theory for G protein-coupled receptors (GPCRs)
  • Developing better beta-2 adrenoceptor ligands for asthma therapy
  • Quantifying ligand bias for beta-2 adrenoceptor ligands
  • Examining possible better therapeutics for heart failure
  • B.A. Science, St. Thomas of Villanova, Miami, Fla.
  • B.S. Pharmacy, University of Houston College of Pharmacy, Houston, Texas
  • Ph.D. Pharmacology, University of Houston College of Pharmacy, Houston, Texas


Google Scholar Profile
  • *Milano, C.A., Allen, L.F., Dolber, P., Rockman, H., Chien, K.R., Johnson, T.D., Bond R.A., Lefkowitz, R.J.: Enhanced myocardial function in transgenic mice with cardiac overexpression of the human β2 -adrenergic receptor. Science, 264: 582-586, 1994. PMID: 8160017
  • *Milano, C.A., Dolber, P.C., Bond R.A., Venable, M., Allen, L.F. and Lefkowitz, R.J.: Myocardial expression of a constitutively active alpha1B-adrenergic receptors in transgenic mice induces cardiac hypertrophy. Proc. Nat. Acad. Sci. (USA), 91: 10109-10113, 1994. PMID: 7937846
  • *Bond R.A., Johnson, T.D., Milano, C.A., Leff, P., Rockman, H.A., McMinn, T., Apparsunduram, S., Hyek, M.F., Kenakin, T.P., Allen, L.F. and Lefkowitz, R.J.: Physiologic effects of inverse agonists in transgenic mice with myocardial overexpression of the beta2-adrenoceptor. Nature, 374:272-276, 1995. PMID: 7885448
  • *Koch, W.J., Rockman, H.R., Samama, P., Bond R.A., Milano, C.A. and Lefkowitz, R.J.: Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a ARK inhibitor. Science, 268: 1350-1353, 1995. PMID: 7761854
  • *Jaber, M., Koch, W.J., Rockman, H.A., Smith, B., Bond R.A., Sulik, K., Ross Jr., J., Lefkowitz, R.J., Caron M.G. and Giros, B.: Essential role of β-adrenergic receptor kinase 1 in cardiac development and function. Proc. Nat. Acad. Sci. (USA), 93: 12974-12979, 1996. PMID: 8917529
  • *Samama, P., Bond R.A., Rockman, H.A., Milano, C.A. and Lefkowitz, R.J.: Ligand-induced overexpression of a constitutively active β2-adrenoceptor: pharmacological creation of a phenotype in transgenic mice. Proc. Nat. Acad. Sci. (USA), 94: 137-141, 1997. PMID: 8990174
  • *Milligan, G. and Bond R.A.: Inverse agonism and the regulation of receptor number. Trends Pharmacol. Sci., 18: 468-474, 1997. PMID: 9458695
  • *Clarke, W.P. and Bond R.A.: The elusive nature of intrinsic efficacy. Trends Pharmacol. Sci., 19: 270-276, 1998. PMID: 9703760
  • Callaerts-Vegh, Zs., Evans, K.J., Shipley, G.L., Davies, P.J.A., Cuba, D.L., Gurji, H.A., Giles, H. and Bond R.A.: Effects of different beta-adrenoceptor ligands in mice with permanent occlusion of a coronary artery. Br. J Pharmacol. 138: 1505-16, 2003. PMID: 12721106
  • *Flesch, M., Hoper, A., Evans, K.J., Bond R.A., Peshock, R., Diwan, A., Brinsa, T.A.,n Wei, C-C., Sivasubramanian, N., Spinale, F.G. and Mann, D.: Activation and functional significance of the renin angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 108: 598-604, 2003. PMID: 12874189
  • *Callaerts-Végh Zs, Evans KLJ, Dudekula N, Cuba D, Knoll BJ, Callaerts P, Giles H, Shardonofsky FR, Bond RA.: Effects of acute and chronic administration of β-adrenoceptor ligands on airway function in a murine model of asthma. Proc. Nat. Acad. Sci. 101: 4948-4953, 2004. PMID: 15069206
  • *Nguyen, L., Omoluabi, Parra, S., Frieska, J.M, Clement, C., Ammar-Aouchiche, Z., Ho, S.B., Ehre, C., Kessimer, M., Knoll, K.J., Tuvin, M., Dickey, B.F. and Bond R.A.: Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol. 38: 256-262, 2008. PMID: 18096872
  • *Nguyen, L., Lin, R., Omoluabi, O., Hanania, N., Tuvim, M., Knoll, B., Dickey, B.F., Bond R.A.: β2-adrenoceptor signaling is required for the development of the asthma phenotype in a murine model. Proc. Nat. Acad. Sci. 101: 4948 – 4953, 2009. PMID: 19171883
  • Forkuo, G.S., Hosu, K., Thanawala, V.J., Al-Sawalha, N., Valdez, D., Radhika, J., Walker, J.K.L., Penn, R.B., and Bond R.A.: Administration of PDE4 inhibitors in mice lacking epinephrine attenuates restoration of the asthma phenotype produced by β2-adrenoceptor agonists. Am J Respir Cell Mol Biol. 55:234-42, 2016. PMID:26909542
  • Long P. Nguyen, Nour Al-Sawalha, Sergio Parra Indira Pokkunuri, Ozozoma Omoluabi, Adedoyin A. Okulate, Elizabeth Windham Li, Jose M. Gonzalez-Granado, Craig J. Daly, John C. McGrath, Michael J. Tuvim, Brian J. Knoll, Burton F. Dickey and Richard A. Bond: β2-Adrenoceptor Signaling in Airway Epithelial Cells Promotes Eosinophilic Inflammation, Mucous Metaplasia, and Airway Hyperresponsiveness. Proc. Nat. Acad. Sci. 114: E9163-E9171, 2017. PMID: 29073113

Awards & Honors

  • 2019 – Included on a list of the top 2% most cited scientists.
  • 2019 – Faculty Excellence in Service Award for the College of Pharmacy, University of Houston.
  • 2018 – University of Houston Provost Teaching Excellence Award for Group Teaching in Cardiovascular and Renal Pharmacology Graduate Course.
  • 2018 - McMaster University Honours Biology & Pharmacology Program "11th Annual Biology & Pharmacology Lectureship" (first repeat invitation; see list of previous invitees at:
  • 2017 – Appointed Honorary Fellow of the British Pharmacological Society (the Society’s highest honor)
  • 2016 – Appointed Fellow of the British Pharmacological Society (FBPhS)
  • 2015 – University of Houston Provost’s 'Certificate of Excellence' awarded for 'Extraordinary Achievements' by the Provost
  • 2003 – 2009 – Fellow of the American Asthma Foundation
  • 2000 - Faculty Excellence Award from University of Houston, College of Pharmacy
  • 1999 - Established Investigator’s Award from the American Heart Association
  • 1997 - Named one of the 100 Most Influential Hispanics by Hispanic Business magazine
  • 1996 - Faculty Excellence Award from Univ. of Houston, College of Pharmacy
  • 1995 - Teaching Award from Council of Campus Leaders, University of Houston