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Faculty Profile

Amy K. SaterGeorge Reiter

Professor
Department of Physics

Office: Science & Research 1, 619B
Contact: greiter@uh.edu - (713) 743-3527

Education: Ph.D., Stanford University

Google Scholar Profile
Website

Deep Inelastic Neutron Scattering

Measurement of momentum distributions and Born-Oppenheimer potentials in solids and liquids
Quantum mechanics of nano-confined water

Complex Systems

Pre dna evolution

Dynamics of Economic Systems

We previously identified ashwin, a novel highly conserved gene, in a differential display screen for genes expressed at initial stages of neural specification. Ashwin is a transcriptional repressor, and overexpression of ashwin leads to a puzzling combination of phenotypes, including both double-axis, or twinned, embryos, and embryos with anterior truncations. Our working hypothesis is that both phenotypes result from localized inhibition of the anterior organizer, although ashwin apparently has multiple targets at different developmental stages. Loss-of-function studies suggest that ashwin regulates cell survival, and it may also be required for the establishment of posterior pattern. We are currently investigating the mechanisms of ashwin action and its role in early development.

  • Traverso EE, Cho MS, Wu CF, Sater, A.K., Larabell CA, Kloc M, Etkin LD. (2007). Disruption of the dynamic sub-cellular localization of the Xenopus tumorhead protein causes embryonic lethality at the early gastrula transition. Differentiation, 75(10):947-56.
  • Sater, A.K., and El-Hodiri, H. M. Analysis of MAP kinase pathways in vertebrate development. In (M. Whitman and A. K. Sater, eds.) Analysis of Growth Factor Signaling in Embryos, CRC Press, Boca Raton FL. In press (Spring 2006).
  • Patil SS, Alexander TB, Uzman JA, Lou CH, Gohil H, Sater, A.K. (2006). Novel gene ashwin functions in Xenopus cell survival and anteroposterior patterning. Developmental Dynamics, 235(7):1895-907.
  • Klein SL, Gerhard DS, Wagner L, Richardson P, Schriml LM, Sater, A.K., Warren WC, McPherson JD. (2006). Resources for genetic and genomic studies of Xenopus. Methods in Molecular Biology, 322:1-16.
  • Klein, S. L., Gerhard, D. S., Wagner, L., Richardson,, P., Schriml, L., Sater, A.K., Warren, W. C., and McPherson,, J. D. (2005). Resources for Genetic and Genomic Studies of Xenopus. In Johné, L.X. (Ed), Methods in Molecular Biology. Xenopus Protocols: Cell Biology and Signal Transduction. Xenopus Protocols; Cell Biology and Signal Transduction, Humana Press, Totowa, NJ.
  • Kim, S. K., Park,J.-I., Spring, C. M., Sater, A.K., Ji, H., Otchere, A. A., Daniel, J. M., and McCrea P. D. (2004). Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Nature Cell Biology 6, 1212-1220.
  • Sater, A.K., El-Hodiri, H.M., Goswami, M., Alexander, T. B., Al-Sheikh, O., Etkin, L. D., and Uzman, J. A. (2003). Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification. Differentiation 71, 434-444.
  • Uzgare, A. R., Goswami, M., and Sater, A.K. (2001). Regulation of MAPK activity by the BMP-4 pathway in Xenopus ectoderm. Developmental Biology 236, 259-270.

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