Department of Biology and Biochemistry
Office: Science & Engineering Research Center, 3009
Contact: email@example.com - 832-842-8824
Education: Ph.D., University of North Carolina at Chapel Hill, M.S., East China Normal University, B.S., East China Normal University
Google Scholar Profile
Chromatin Biology and Epigenetic Regulation of Gene Expression in Human Diseases
Epigenetics is defined as the study of heritable changes caused by mechanisms other than alterations in the DNA sequence. Core histones, the fundamental units of chromatin structure, are subjected to many types of post-translational modifications such as acetylation, methylation, phosphorylation, ubiquitination, crotonylation, etc.
Depending on the types and locations, these modifications can regulate gene expression either positively or negatively. Aberrant gene expression caused by deregulated epigenetics plays a key role in the initiation and progression of many diseases.
There are three major classes of proteins: writers, readers, and erasers. They add, recognize, and remove the epigenetic modifications on chromatin, consequently affecting transcription. As a result, many of these proteins have emerged as therapeutic targets. In Dr. Qin Feng’s lab, the goal is to understand the molecular events that lead to aberrant regulation of gene expression in human diseases, such as HIV and breast cancer, and ultimately develop novel therapeutic agents.
Honors & Awards
- 2014–16, AIDS Society/NIH/CFAR Creative and Novel Ideas in HIV Research Award
- 2013–16, DOD CDMRP Breast Cancer Research Program Idea Award
- 2011–13, NIDDK Diabetes Research Center Pilot and Feasibility Grant Award
- 2009–13, NIDDK Mentored Research Scientist Development Award (K01)
- 2007–09, NIDDK Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32)
- 2006, Endocrine Society Annual Meeting Travel Award
- 2006, Endocrine Scholar Award
- 2005, Scientific Presentation Award in the Society of Chinese Bioscientists in North America-Texas Annual Symposium
- 2003, University of North Carolina Lineberger Comprehensive Cancer Center Graduate Fellow Award
Organizations, Outreach, Boards, Memberships
- 2014–2016, Member of AIDS Society
- 2004–2012, Member of Endocrine Society