Department of Biology and Biochemistry
Office: Houston Science Center, 352
Contact: firstname.lastname@example.org - (713) 743-7941
Education: Ph.D., Johns Hopkins University
Dr. Yuhong Wang is a biophysicist interested in developing new methods to study biological questions. Her lab is applying/developing single molecule fluorescence microscopy to study the ribosome translation mechanism. They have developed a FRET system that specifically monitoring the peptidyl transfer reaction mechanism and the tRNA dynamics during translation cycles. Wang also studies the translational kinetics and its effects on co-translational foldings.
Meanwhile, Wang is applying/developing a magnetic sensing method to determine the mechanical forces generated in translation to warrant speed and fidelity. Her group has developed a unique cutting-edge atomic magnetometry using nucleic acid duplexes to measure the forces precisely.
Wang is interested in studying the antibiotic inhibition mechanism and developing new antibiotics. She is also interested in developing non-invasive, sensitive early detection of cancer biomarkers from minimal bio samples or body fluids.
- Hu, Q., Yang, H., Wang, Y. & Xu, S.-J. Quantitatively Resolving Multivalent Bonds on Macroscopic Scale Using Force Spectroscopy. Chem. Commun. 52, 3705-3708 (2016).
- Yao, L.; Wang, Y.; Xu, S.-J. Ultrasensitive microRNA sequencing using exchange-induced remnant magnetization. Chem. Commun. 49, 5183-5185 (2013).
- Yao,L; Li, Y.; Tsai, T.-W.; Xu, S.-J.; Wang, Y. Noninvasive measurement of the mechanical force generated by motor protein EF-G during ribosome translocation. Angew. Chem. Int. Edit. 52, 14041-14044 (2013).
- De Silva, L.; Yao, L.; Wang, Y.; Xu, S.-J. Well-defined and sequence-specific noncovalent binding forces of DNA. J. Phys. Chem. B 117, 7554-7558 (2013).
- Wang, Y.; Xiao, M. Role of the ribosomal protein L27 revealed by single-molecule FRET study. Protein Sci. 21, 1696-1704 (2012).