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Department of Biology and Biochemistry

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Faculty Profile

Richard BondRichard Bond

Associate Professor of Pharmacology
Pharmacological and Pharmaceutical Sciences Department

Office: SR2 453 E
Contact: rabond@uh.edu - (713) 743-1210

Education: Ph.D., University of Houston

Pharmacology of receptor theory

Characterization and classification of G protein-coupled receptors

  • Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M, Knoll BJ, Tuvim MJ, Dickey BF, Bond RA. (2008). Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. American Journal of Respiratory Cell and Molecular Biology, 38(3), 256-62.
  • Hanania NA, Singh S, El-Wali R, Flashner M, Franklin AE, Garner WJ, Dickey BF, Parra S, Ruoss S, Shardonofsky F, O'Connor BJ, Page C, Bond RA. (2008). The safety and effects of the beta-blocker, nadolol, in mild asthma: An open-label pilot study. Pulmonary Pharmacology & Therapeutics, 21(1), 134-41.
  • Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA. (2008). Changes in beta(2)-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulmonary Pharmacology & Therapeutics, 21(1), 115-24.
  • Bond RA, Spina D, Parra S, Page CP. (2007). Getting to the heart of asthma: can
  • Parra S, Bond RA. (2007). Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant? Current Opinion In Pharmacology, 7(2):146-50.
  • Bond RA, Ijzerman AP. (2006) Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends In Pharmacological Sciences, 27(2):92-6.
  • Bond RA. (2006). A proposal for a national program reporting beneficial drug responses, analogous to the existing program to detect adverse drug responses. Medical Hypotheses, 66(1):10-3.
  • Evans, K.J., Callaerts-Vegh, Zs., Fleetwood, G., Cuba, D., Giles, H., Schardonofsky, F. and Bond, R.A.: Efffects of long-term beta-adrenoceptor blockade on the phenotype of a murine model of asthma. Submitted
  • Edwards, S., Hoyler, S.L., Bond, R.A., Wilcox, R.E.: Sensitization of ß2-adrenoceptor mediated cAMP generation after exposure to inverse agonists. In preparation.
  • Callaerts-Vegh Z, Evans KL, Dudekula N, Cuba D, Knoll BJ, Callaerts PF, Giles H, Shardonofsky FR, Bond RA. (2004). Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America, 101(14): 4948-53.
  • Evans, K.J., Bond, R.A., Corry, D., and Shardonofsky, F.: Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma. J. Applied Physiol. 94: 245-252, 2003.
  • Callaerts-Vegh, Zs., Evans, K.J., Shipley, G.L., Davies, P.J.A., Cuba, D.L., Gurji, H.A., Giles, H. and Bond, R.A.: Effects of different beta-adrenoceptor ligands in mice with permanent occlusion of a coronary artery. Br. J. Pharmacol. 138: 1505-1516, 200
  • Bond, R.A., Corry, D., and Shardonofsky, F.: Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma. J. Applied Physiol. 94: 245-252, 2003.
  • Callaerts-Vegh, Zs., Evans, K.J., Shipley, G.L., Davies, P.J.A., Cuba, D.L., Gurji, H.A., Giles, H. and Bond, R.A.: Effects of different beta-adrenoceptor ligands in mice with permanent occlusion of a coronary artery. Br. J. Pharmacol. 138: 1505-1516, 200
  • Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H. (2003). Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation, 108(13):1633-9.
  • Bond, R.A.: Can intellectualism stifle scientific discovery? Nature Rev. Drug Discovery. 10: 825-829, 2002.
  • Liu, X., Callaerts-Vegh, Zs., Evans, K. and Bond, R.A.: Chronic Infusions of Antagonists and Inverse Agonists Produces Heterologous Sensitization in Transgenic Mice with Cardiac-Specific Overexpression of the Human ß2-adrenoceptor J. Cardiovasc. Pharmacol
  • Liu X, Callaerts-Vegh Z, Evans KL, Bond RA. (2002). Chronic infusion of beta-adrenoceptor antagonist and inverse agonists decreases elevated protein kinase A activity in transgenic mice with cardiac-specific overexpression of human beta 2-adrenoceptor. Journal Of Cardiovascular Pharmacology, 40(3):448-55.
  • Bond, R.A.: Is Paradoxical Pharmacology a strategy worth pursuing? Trends Pharmacol. Sci 22: 273-276, 2001.
  • Bylund, D.B., Bond, R.A., Bouvier, M., Clarke, D.E., Eikenburg, D.C., Hieble, J.P., Kobilka, B.K., Langer, S.Z., Lefkowitz, R.J., Minneman, K.P., and Ruffolo, R.R.: Adrenoceptors. The IUPHAR compendium of receptor characterization and classification, 88-1
  • Franceshini, D., Orr-Urtreger, A., Yu, W. Mackey, L.Y., Bond, R.A., Armstrong, D., Patrick, J.W., Beaudet, A.L., and De Bisai, M.: Altered baroreceptor reflex in a7 deficient mice. Behav. Brain Res. 113: 3-10, 2000.
  • Nagaraja, N., Iyer, S., Liu, X., Eichberg, J. and Bond, R.A.: Enhanced ß2-Adrenoceptor Response To Isoprenaline After Chronic Treatment With ß2Adrenoceptor Inverse Agonists. Br. J. Pharmacol., 127: 1099-1104, 1999.
  • Clarke, W.P. and Bond, R.A.: The elusive nature of intrinsic efficacy. Trends Pharmacol. Sci., 19: 270-276, 1998.
  • Bond, R.A.: Do recent operational studies indicate that a single state model is no longer applicable to G protein-coupled receptors? Annals of the New York Academy of Sciences, 812: 92-97, 1997.
  • Milligan, G. and Bond, R.A.: Inverse agonism and the regulation of receptor number. Trends Pharmacol. Sci., 18: 468-474, 1997.