Dr. Markofski's overarching research question is How do exercise and nutrition encourage healthy aging? We know that people who are physically active have a lower risk of chronic diseases and decreased mortality, but what are the mechanisms for this benefit? Dr. Markofski is primarily interested in the contribution of the immune system and skeletal muscle to healthy aging, but acknowledges that these systems are influenced by other physiological processes.
Many of the diseases typically associated with aging may not be related to aging per se, but rather an age-associated decrease in physical activity and increase in sedentary time. These changes in physical activity cause numerous changes to physiology, including to the immune system, adipose tissue, and skeletal muscle—and cause an increase in the risk for developing chronic diseases. Dr. Markofski approaches her research questions by studying the acute and chronic effects of exercise and nutrition on skeletal muscle and immune function. She is an exercise physiologist with a research agenda in exercise immunology. Her current projects encompass healthy research participants, cancer patients and survivors, and health disparities.
Recent Publications and Research Activity
(selected publications. Full list in CV)
Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ. β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018 Aug 30. [Epub ahead of print] PMID: 30172948
Gupta P, Bigley AB, Markofski M, Laughlin M, LaVoy EC. Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 2018 Jul;71:81-92. PMID: 29656052
Hong J, Kim K, Park E, Lee J, Markofski MM, Marrelli SP, Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in mesenteric arteries in atherosclerosis. Sci Rep. 2018 May 21;8(1):7938. PMID: 29784903
Markofski MM, Jennings K, Timmerman KL, Dickinson JM, Fry CS, Borack MS, Reidy PT, Deer RR, Randolph A, Rasmussen BB, Volpi E. Effect of aerobic exercise training and essential amino acid supplementation for 24 weeks on physical function and muscle metabolism in healthy, independent older adults: a randomized clinical trial. J Gerontol Med Sci. Epub 2018 May 10. PMID: 29750251
Carrillo AE, Markofski MM, Flynn MG. Elevated inflammatory status and increased risk of chronic disease in chronological aging: Inflamm-aging or inflamm-inactivity? Aging and Disease. 2018 Dec; 9(6):xxx-xx
Agha NH, Baker FL, Kunz HE, Graff R, Azadan R, Dolan C, Laughlin MS, Hosing C, Markofski MM, Bond RA, Bollard CM, Simpson RJ. Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor. Brain Behav Immun. 2018 Feb;68:66-75. Epub 2017 Oct 7. PMID: 29017969
Arlinghaus KR, Markofski MM, Johnston CA. Reducing anxiety to increase exercise in individuals with decreased lung capacity. Am J Lifestyle Med. 2017 April;11(4):307-309.
Reidy PT, Borack MS, Markofski MM, Dickinson JM, Fry CS, Deer RR, Volpi E, Rasmussen BB. Post-absorptive muscle protein turnover affects resistance training hypertrophy. Eur J Appl Physiol. 2017 May;117(5):853-866. PMID: 28280974
Borack MS, Reidy PT, Husaini SH, Markofski MM, Deer RR, Richison AB, Lambert BS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men. J Nutr. 2016 Dec; 146(12):2468-2475. PMID: 27798330
Reidy PT, Borack MS, Markofski MM, Dickinson JM, Deer RR, Husaini SH, Walker DK, Igbinigie S, Robertson SM, Cope MB, Mukherjea R, Hall-Porter JM, Jennings K, Volpi E, Rasmussen BB. Protein supplementation has minimal effect on muscle adaptations during resistance exercise training in young men: a double-blind randomized clinical trial. J Nutr. 2016 Sept; 146(9):1660-9. PMID: 27466602
Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon-Jones D, Reidy PT, Sheffield-Moore M, Timmerman KL, Rasmussen, BB, and Volpi E. Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol. 2015 May;65:1-7. PMID: 25735236
Timmerman KL, Amonette WE, Markofski MM, Ansinelli HA, Gleason EA, Rasmussen BB, and Mossberg KA. Impaired IL-6 and IL-10 response to exercise in patients with traumatic brain injury. Eur J Appl Physiol. 2015 Jan;115(1):111-8.
Markofski MM, Flynn MG, Carrillo AE, Armstrong C, Campbell WW, and Sedlock, DA. Exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage with and without weight loss in overweight and obese adults. Eur J Appl Physiol. 2014 Aug;114(8):1737-48.
Markofski MM and Braun WA. Influence of menstrual cycle on indices of contraction-induced muscle damage. J Strength Cond Res. 2014 Sep;28(9):2649.
Markofski MM, Carrillo AE, Timmerman KL, Jennings K, Coen PM, and Flynn MG. Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):675-81.
Drummond MJ, Timmerman KL, Markofski MM, Walker DK, Dickinson JM, Jamaluddin M, Brasier AR, Rasmussen BB, Volpi E. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R216-23.
Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013 Jun;32(3):375-81
Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22.
Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects. Eur J Appl Physiol. 2012 Aug;112(8):3045-52
Markofski MM and Volpi E. Protein metabolism in women and men: similarities and disparities. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):93-7.
Coen PM, Flynn MG, Markofski MM, Pence BD, Hannemann RE. Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population. Metabolism. 2010 Dec;59(12):1775-83.
B.S. in Kinesiology at California State Polytechnic University, Pomona, 2000
M.S. in Kinesiology at California State Polytechnic University, Pomona, 2004
Ph.D. in Health & Kinesiology at Purdue University, 2010