Skip to main content


Dr. Marc Hamilton


Office Number: 2064 H2
Phone: 713-743-1115
Fax: 713-743-9860


Mailing Address:
3875 Holman St., Rm 104 Garrison
Houston, TX 77204-6015

Research Interests

My laboratory performs translational research that integrates both molecular and behavioral studies. This innovative approach is necessary to discover an effective public health solution to prevent and manage conditions adversely impacted by sedentary living (aging, diabetes, obesity, some cancers, dementia, and cardiovascular disease). The goal is for a scalable solution that can most feasibly provide the metabolic benefits of a high duration of muscular activity for people living with poverty, pre-existing health conditions, or other reasons associated with excessive sedentary time.

Recent Publications and Research Activity

Representative Publication Examples:

Hamilton MT, Hamilton DG, Zderic TW. Sedentary behavior as a mediator of type 2 diabetes. Med Sport Sci, 2014 Hamilton MT, Hamilton DG, Zderic TW. Med Sport Sci 2014;60:11-26, 2014.

Hamilton MT, Hamilton DG, Zderic TW. The Role of Low Energy Expenditure and Sitting on Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease. Diabetes 56(11): 2655-2667, 2007.

Hamilton, MT, Healy GN, Zderic TW, Dunstan DW, Owen N. Too Little Exercise and Too Much Sitting: Inactivity Physiology and the Potential Need for New Recommendations on Sedentary Behavior. Current Cardiovascular Risk Reports, 2: 292-298, 2008.

Hamilton, M.T., D.G. Hamilton, T.W. Zderic. Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulation. Exerc. Sports Sci. Rev. 32(4): 161-166, 2004.

Zderic TW, Hamilton MT. Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting). Lipids Health Dis. Oct 12;11:137, 2012.

Zderic, T.W., and M.T. Hamilton. Physical inactivity amplifies the sensitivity of skeletal muscle to the lipid-induced downregulation of lipoprotein lipase activity. J. Appl. Physiol. 100(1): 249-257, 2006

Craft LL, Zderic TW, Gapstur SM, Vaniterson EH, Thomas DM, Siddique J, Hamilton MT. Evidence that women meeting physical activity guidelines do not sit less: An observational inclinometry study. Int. J. Behav. Nutr. Phys. Act., Oct 4; 9:122, 2012.

Newton RL, Han H, Zderic TW, Hamilton MT. The energy expenditure of sedentary behavior: a whole room calorimeter study. PLoS One May 3;8(5):e63171, 2013.

Bey, L and MT Hamilton. Suppression of Skeletal Muscle Lipoprotein Lipase Activity: a Molecular Reason to Maintain Daily Low-Intensity Activity. J. Physiol. (London) 551.2: 673-682, 2003.

Bey L, N. Akunuri, E.P. Hoffman, P. Zhao, D.G. Hamilton, and M.T. Hamilton. Patterns in global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity. Physiol. Genomics 13(2):157-167, 2003.

Bey L, E. Areiqat, A. Sano, and M.T. Hamilton. Reduced lipoprotein lipase activity in postural skeletal muscle during aging. J. Appl. Physiol. 91(2): 687-692, 2001.

Hamilton M.T., and Owen N. Sedentary Behavior and Inactivity Physiology. In: Physical Activity and Health, 2nd edition, C. Bouchard, S.N. Blair, and W. L. Haskell (Eds.). Human Kinetics, 2011.

Owen N., and M.T. Hamilton. Sedentary Time and Obesity. In: Handbook of Obesity - Volume 1: Epidemiology, Etiology, and Physiopathology, Third Edition, G.A. Bray and C. Bouchard (Eds.), CRC Press, Taylor and Francis Group, Boca Raton FL, 367-375, 2014.

Representative Funding Examples:

Adaptive Effects of Reducing Daily Sedentary Time in Adults
American Diabetes Association 2015-2017

The Evolutionary Biology and Health Consequences of Human Inactivity
National Science Foundation 2015-2017

Understanding and limiting the physiological effects of sedentary behaviors
The Edward G. Schlieder Educational Foundation 2010-2013

Obesity (Positive Energy Balance): Too Much Food and Too Little Activity
USDA 2010-2012

Vascular biology: exercise training and vascular disease
National Institutes of Health Program Project (National Heart Lung Blood Institute) 2006-2011


B.A. in Zoology at University of Texas-Austin, 1987

M.A. in Exercise Physiology at University of Texas-Austin, 1989

Ph.D. in Exercise Science at University of South Carolina, Columbia, 1994

Postdoctoral Fellowship in Physiology, Cell Biology and Pharmacology at University of Texas School Medical School, Houston, 1997