Exercise/Physical Activity and Cardiovascular Health:
1. To investigate the protective role of physical activity and exercise training in vascular (endothelial) dysfunction in the various pathophysiologic conditions such as obesity, type 2 diabetes, atherosclerosis, aging (Alzheimer), microgravity, etc. in animal and human models
2. To elucidate the underlying mechanisms in which vascular function is altered by the sequelae of the diseases and physical activity/exercise training at the molecular, cellular, and intact tissue levels using isolated intact microvessels.
Recent Publications and Research Activity
Lee J, Hong J, Umetani M, LaVoy E, Kim J, *Park Y. Vascular protection by exercise in obesity: inflammasome-associated mechanisms. Med Sci Sports Exerc. 2020. (In Print)
Hong J, Hong SK, Lee J, Park JY, Eriksen JL, Rooney BV, and *Park Y Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer’s disease: role of the P2Y2 receptor and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol. 2020. Jun 1;318(6):H1559-H1569. doi: 10.1152/ajpheart.00129.2020.
Kwon I, Kim JS, Shin CH, Park Y, Kim JH. Associations Between Skeletal Muscle Mass, Grip Strength, and Physical and Cognitive Functions in Elderly Women: Effect of Exercise with Resistive Theraband.J Exerc Nutrition Biochem. 2019 Sep 30;23(3):50-55
Jung J, Seo DI, Park Y, So WY. Echocardiography evaluation of left ventricular diastolic function in elderly women with metabolic syndrome. Open Medicine. 2019 Aug. doi: 10.1515/med-2019-0073
Son Y, Kim K, Jeon S, Kang M, Lee S, *Park Y. Response to: Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis" Int J Vasc Med. 2019 Feb 5;2019:2470581. doi: 10.1155/2019/2470581
Lee J, Lee Y, LaVoy E, Umetani M, Hong J, *Park Y. Physical Activity Protects NLRP3 inflammasome-induced Vascular Dysfunction in Obesity. Physiol. Rep. 2018. Jun;6(12):e13738. doi: 10.14814/phy2.13738.
Hong J, Kim K, Park E, Lee J, Markofski MR, Marrelli SP, and *Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in atherosclerotic mesenteric arteries. Sci Rep. 2018 8:7938 | DOI:10.1038/s41598-018-26188-9. 2018
Lee J, Lee R, Hwang MH, Hamilton MT, *Park Y. The effects of exercise on vascular endothelial function in type 2 diabetes: A Systematic Review and Meta-analysis. Diabetol Metab Syndr. 2018 Mar 6;10:15. doi: 10.1186/s13098-018-0316-7. 2018
Lee J, Lee S, Zhang H, Hill MA, Zhang C, *Park Y. Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mice heart. PLoS ONE. 2017 Nov 2;12(11):e0187189. doi: 10.1371/journal.pone.0187189. 2017
Son Y, Kim K, Jeon S, Kang M, Lee S, *Park Y. Effect of exercise intervention on flow-mediated dilation in overweight and obese adults: Meta-analysis. Int J Vasc Med. 2017;7532702. doi: 10.1155/2017/7532702. 2017
So WY, Lee SY, Park Y, Seo DI. Effects of 4 weeks of horseback riding on anxiety, depression, and self-esteem in children with attention deficit hyperactivity disorder. J Mens Health. 2017– 13(2):e1-e7; September 28, 2017
Hong J, Kim K, Kim J, *Park Y. The role of endoplasmic reticulum stress in cardiovascular disease and exercise. Int J Vasc Med. 2017:2049217. doi: 10.1155/2017/2049217. 2017
Chen X, Zhang H, Hill MA, Zhang C, *Park Y. Regulation of coronary endothelial function affected by feedback among TNF-α, LOX-1 and adiponectin in ApoE knockout mice. J Vasc Res. 52(6):372-82. 2016
Kim JH and *Park Y. The combined effects of phytochemicals and exercise on fatty acid oxidation. J Exerc Nutrition Biochem. 20(4);20-26. 2016
Ghosh P, Behnke BJ, Stabley JN, Kilar CR, Park Y, Muller-Delp JM, Alwood JS, Shirazi-Fard Y, Schreurs NS, Globus RK, Delp MD. Effects of high-LET radiation and hindlimb unloading on skeletal muscle resistance artery vasomotor properties in mice. Radiation Research. Mar;185(3):257-66. 2016
Kunz H, Bishop NC, Spielmann G, Pistillo M, Reed J, Ograjsek T, Park Y, Mehta SK, Pierson DL, Simpson RJ. Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise. Eur J Appl Physiol. 115(5):1015-27. 2015
Park Y, Prisby RB, Lesniewski LA, Donato AJ, Delp MD. Effects of aging and exercise training on Angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles, J Appl Phsiol., Oct;113(7):1091-100. 2012
*Park Y, Booth FW, Lee S, Laye MJ, and Zhang C. Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice. J Physiol (Lond). Sep;1;590(Pt 17):4255-68. 2012
Lee S, Park Y, Zhang C. exercise training prevents coronary endothelial dysfunction in type 2 diabetic mice. Am. J. Biomed. Sci 3(4): 241-252. 2011
Lee S, Park Y, Dellsperger KC, Zhang C. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. Aug;301(2):H306-14. 2011
Park Y, Yang J, Zhang H, Chen X and Zhang C. Role of PAR2 in the regulation of TNF-α-induced endothelial dysfunction in type 2 diabetic mice. Basic Res Cardiol. Jan;106(1):111-23. 2011
Zhang H, Park Y, Liu Y and Zhang C. Coronary and aortic endothelial function affected by feedback between adiponectin and TNF-α in type 2 diabetic mice. Arterioscler Thromb Vasc Biol. Nov;30(11):2156-63. 2010
Yang J, Park Y, Zhang H, Gao X, Wilson E, Zimmer W, Abbott L and Zhang C. Role of MCP-1 in tumor necrosis factor alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 297(4):H1208-16. 2009
Yang J+, Park Y+, Zhang H, Xu X, Laine GA, Dellsperger KC and Zhang C (+Co-first authors). Feed-forward signaling of TNF-α and NFκB via IKKβ pathway induces insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 296(6):H1850-8, 2009
Park Y, Capobianco S, Gao X, Falck JR, Dellsperger KC and Zhang C. Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol. 295(5):H1982-8, 2008
Zhang C, Park Y, Picchi A and Potter BJ. Maturation-induced endothelial dysfunction via vascular inflammation in diabetic mice. Basic Res Cardiol. 103(5):407-16. 2008
Gao X, Park Y, Capobianco S, Yang J, Zhang H, Picchi A and Zhang C.. Role of TNF alpha in prediabetic metabolic syndrome induced endothelial dysfunction. 8th World Congress for MICROCIRCULATION (Ed. Julian H Lombard). MEDIMOND S.r.l., International Proceedings., H815R9145: P179-185. 2007
Selected Funded Grants
ACTIVE RESEARCH SUPPORT
NASA (NRA- NNJ16ZSA001N-SRHHC). Role: Co-Investigator (PI: Michael Delp). “Radiation, Simulated Weightlessness and Countermeasures: Effects on Cerebral and Coronary Vascular Function and Structure.” June 2018 – May 2021.
Korea Institute of Robot and Convergence (KIRO). Role: Co-Investigator (PI: Beom-Chan Lee). “Developing and Assessing Wearable Technologies to Predict and Prevent Falls.” June 2017 - December 2022.
American College of Sports Medicine (ACSM, Foundation Doctoral Student Research Grant) Role: Supervisor. (PI: Junyoung Hong, doctoral student). “The effect of exercise on purinergic receptor-mediated cerebrovascular dysfunction in Alzheimer’s Disease.”July 2018 – June 2019.
COMPLETED RESEARCH SUPPORT
CardioVascular Research Foundation. Role: Principal Investigator, “The Effect of Aerobic Exercise on Coronary Arterial Endothelial Function in ApoE-/- Mice – The Role of Liver X Receptor (LXR) and Uncoupling Protein-2 (UCP-2).” June 2015 – January 2017.
B.A. in Physical Education at Seoul National University, 1997
M.A. in Clinical Exercise Physiology at Seoul National University, 1999
M.A. in Exercise Physiology at University of Texas at Austin, 2003
Ph.D. in Exercise Physiology at Texas A&M University, 2006
Post-doc in Internal Medicine at Division of Cardiovascular Medicine, University of Missouri, 2010