A Small Molecule Activator of the TET2 Tumor Suppressor
Tuesday, May 3, 2022
12:00 pm - 1:00 pm
About the Event
TET2 is a tumor suppressor gene that is frequently mutated in hematological cancers. TET2 protein is an enzyme that catalyzes the oxidation of 5-methyl-cytosine and DNA demethylation. Bin Guo, Ph.D., discovered a small molecule compound that directly activates the enzyme activity of TET2. It has demonstrated strong antitumor activity in leukemia cells and mouse models.
About the Speaker
Bin Guo has a broad background and research expertise in both cancer pharmacology and drug discovery. His current research focuses on developing new cancer therapeutics including RNA nanoparticle-carried small RNAs and small molecule drugs targeting epigenetic regulators. His lab has published papers in high-impact journals (including Nature Nanotechnology, Gastroenterology, and Cancer Research).