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Profile: Evan Zasowski

Divya Varkey
Evan Zasowski, Pharm.D., BCPS
Clinical Assistant Professor
Department of Pharmacy Practice and Translational Research

Health and Biomedical Sciences Building 2
4849 Calhoun Road, Room 4013
Houston, TX 77204-5039

713-743-7404
ezasowski@uh.edu

Education

Doctor of Pharmacy
Albany College of Pharmacy and Health Sciences, Albany, NY

Postgraduate Training

Postdoctoral Research Fellowship – Infectious Diseases
Anti-Infective Research Laboratory, Wayne State University, Detroit, MI

Postgraduate Year One Pharmacy Residency
The University of Chicago Medicine, Chicago, IL

Postdoctoral Research Assistant
Albany College of Pharmacy and Health Sciences, Albany, NY

Research Interests

My research focuses on the epidemiology and clinical outcomes of patients with invasive antibiotic-resistant infections, predominantly methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). This includes development and evaluation of methods to identify patients at risk for antibiotic resistance and poor treatment outcomes and evaluation of novel treatment paradigms.

Selected Publications

Finch NA, Zasowski EJ, Murray KP, Mynatt RP, Zhao JJ, Yost R, Pogue JM, Rybak MJ. The Impact of Vancomycin Area Under the Concentration-Time Curve-Guided Dosing on Vancomycin-Associated Nephrotoxicity: a Quasi-Experiment. Antimicrobial Agents and Chemotherapy. 2017 Sep 18 [Epub ahead of print].

Trinh TD, Zasowski EJ, Claeys KC, Lagnf AM, Kidambi S, Davis SL, Rybak MJ. Multidrug-resistant Pseudomonas aeruginosa Lower Respiratory Tract Infections in the Intensive Care Unit: Prevalence and Risk Factors. Diagnostic Microbiology and Infectious Disease. 2017 Sep;89(1):61-66.

Claeys KC, Zasowski EJ, Lagnf AM, Levine DP, Davis SL, Rybak MJ. Novel Application of Published Risk Factors for Methicillin-Resistant S. aureus Acute Bacterial Skin and Skin Structure Infections. International Journal of Antimicrobial Agents. 2017 Jun 28 [Epub ahead of print].

Zasowski EJ, Trinh TD, Claeys KC, Casapao AM, Sabagha N, Lagnf AM, Klinker KP, Davis SL, Rybak MJ. Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections. Antimicrobial Agents and Chemotherapy. 2017 Jan; 61(2). pii:e0215-16.

Claeys KC, Zasowski EJ, Lagnf AM, Nguyen C, Nagel JL, Levine DP, Kaye KS, Davis SL, Rybak MJ. Propensity matched analysis of patients treated with vancomycin versus daptomycin for methicillin-resistant S. aureus bacteremia. Antimicrobial Agents and Chemotherapy. 2016 Sep 23;60(10):5841-8.

Lodise TP, Bidell MR, Flanagan SD, Zasowski EJ, Minassian SL, Prokocimer P. Characterisation of the Haematologic Profile of 21 Days of Tedizolid in Healthy Subjects. Journal of Antimicrobial Chemotherapy. 2016 Sep;71(9):2553-8.

Lagnf AM, Zasowski EJ, Claeys KC, Casapao AM, Rybak MJ. Comparison of Risk Factors and Clinical Outcomes in Polymicrobial versus Monomicrobial Enterococcal Bloodstream Infections. American Journal of Infection Control. 2016 Aug 1;44(8):917-21.

Zasowski EJ, Claeys KC, Lagnf AM, Davis SL, Rybak MJ. Time is of the Essence: the Impact of Delayed Antibiotic Therapy on Patient Outcomes in Hospital-Onset Enterococcal Bloodstream Infections. Clinical Infectious Diseases. 2016 May 15;62(10):1242-50.

Claeys KC, Zasowski EJ, Lagnf AM, Rybak MJ. Comparison of Outcomes between Patients with a Single versus Multiple Positive Blood Cultures for Enterococcus: Infection versus Illusion? American Journal of Infection Control. 2016 Jan 1;44(1):47-9.

Zasowski EJ, Rybak JM, Rybak MJ. The β-Lactams Strike Back: Ceftazidime-Avibactam. Pharmacotherapy. 2015 Aug;35(8):755-70.

Zasowski E, Bland CM, Tam VH, Lodise TP. Identification of Optimal Renal Dosage Adjustments for High Dose Extended-Infusion Cefepime Dosing Regimens in Hospitalized Patients. Journal of Antimicrobial Chemotherapy. 2015 Mar;70(3):877-81.

Lodise TP, Drusano GL, Zasowski E, Dhimess A, Lazariu V, Cosler L, McNutt LA. Vancomycin Exposure in Patients with MRSA Bloodstream Infections: How Much is Enough? Clinical Infectious Diseases. 2014 Sep 1; 59(5):666-75.

Zasowski E, Butterfield JM, McNutt LA, Cohen J, Cosler L, Pai MP, Gottwald L, Chen WZ, Lodise TP. Relationship between time to clinical response and outcomes among Pneumonia Outcomes Research Team (PORT) risk class III and IV patients with community-acquired pneumonia that received ceftriaxone and azithromycin. Antimicrobial Agents and Chemotherapy. 2014 Jul; 58(7):3804-13.

Cardone KE, Grabe DW, Zasowski EJ, Lodise TP. Re-Evaluation of Ceftazidime Dosing Recommendations in Patients on Continuous Ambulatory Peritoneal Dialysis. Antimicrobial Agents and Chemotherapy. 2014 Jan; 58(1):19-26.

Selected Abstracts and Presentations

Zasowski EJ, Trinh TD, Claeys KC, Lagnf AM, Klinker KP, Estrada SJ, Davis SL, Huang V, Potoski BA, Levine DP, Kaye KS, Bonine NG, Gillard P, Rybak MJ. Clinical and Economic Comparison of Ceftaroline Fosamil (CPT) and Daptomycin (DAP) for Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI). 55th Meeting of the Infectious Diseases Society of America (IDSA). San Diego, CA. Oct. 2017. Presenter: Zasowski

Trinh TD, Zasowski EJ, Lagnf AM, Bhatia S, Dhar S, Mynatt RP, Pogue JM, Rybak MJ. Combination Vancomycin/Cefazolin (VAN/CFZ) for Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI). 55th Meeting of the Infectious Diseases Society of America (IDSA). San Diego, CA. Oct. 2017. Presenter: Trinh

Trinh TD, Zasowski EJ, Claeys KC, Lagnf AM, Delaportas D, Estrada SJ, Davis SL, Klinker KP, Huang V, Kaye KS, Bonine NG, Gillard P, Rybak MJ. Ceftaroline Fosamil (CPT) versus Vancomycin (VAN) for Acute Bacterial Skin and Skin Structure Infections (ABSSSI). 55th Meeting of the Infectious Diseases Society of America (IDSA). San Diego, CA. Oct. 2017. Presenter: Trinh

Rybak MJ, Zasowski EJ, Trinh TD, Lagnf AM, Margaritis V, Mendelsohn AB. Risk Factors and Outcomes for Bloodstream Infections (BSI) Among Patients with Acute Bacterial Skin and Skin Structure Infections (ABSSSI). 55th Meeting of the Infectious Diseases Society of America (IDSA). San Diego, CA. Oct. 2017. Presenter: Rybak

Zasowski EJ, Trinh TD, Claeys KC, Lagnf AM, Sabagha N, Sherwin RL, Welch RD, Rybak MJ. Clinical Characteristics of Patients with Skin and Soft tissue Infections (SSTI) Presenting to the Emergency Department: a Focus on Methicillin-Resistant Staphylococcus aureus (MRSA) Risk and Antibiotic Prescribing. 2nd American Society for Microbiology Microbe. New Orleans, LA. June 2017. [5012]. Presenter: Zasowski

Trinh TD, Zasowski EJ, Claeys KC, Lagnf AM, Rybak MJ. Clinical Characteristics and Outcomes of Patients with Skin and Soft Tissue Infections. 2nd American Society for Microbiology Microbe. New Orleans, LA. June 2017. [4626]. Presenter: Trinh

Atwan SM, Merzlyakova M, Zasowski EJ, Trinh TD, Rybak MJ. Impact of Concomitant Cefepime (FEP) on the Outcomes of Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI) Treated with Vancomycin (VAN). 2nd American Society for Microbiology Microbe. New Orleans, LA. June 2017. [3449]. Presenter: Atwan

Zasowski EJ, Murray KP, Trinh TD, Finch NA, Pogue JM, Mynatt RP, Rybak MJ. Identification of Vancomycin Area Under the Curve Exposure-Toxicity Thresholds in Hospitalized Patients. 27th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, AT. April 2017. [6976]. Presenter: Zasowski

Merzlyakova M, Atwan SM, Trinh TD, Zasowski EJ, Rybak MJ. Vancomycin versus Vancomycin plus β-lactam for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections: a Retrospective Cohort Study. 27th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, AT. April 2017. Presenter: Merzlyakova

Trinh TD, Zasowski EJ, Claeys KC, Dryden M, Shlyapnikov S, Khachatryan N, Bassetti M, Kurup A, Rybak MJ. International Validation of a Risk Assessment Tool for Methicillin-Resistant Staphylococcus aureus Acute Bacterial Skin and Skin Structure Infections. 27th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, AT. April 2017. [6301]. Presenter: Trinh

Trinh TD, Zasowski EJ, Lagnf AM, Rybak MJ. Outcomes Associated with Methicillin-Resistant Staphylococcus aureus Pneumonia with Concurrent Bacteremia. 27th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, AT. [6838]. Presenter: Trinh

Zasowski EJ, Trinh TD, Claeys KC, Casapao AM, Rybak MJ. Predictors of Heterogenous Vancomycin-Intermediate Staphylococcus aureus (hVISA) among Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Infective Endocarditis (IE). 1st American Society for Microbiology Microbe. Boston, MA. June 2016. [436]. Presenter: Zasowski

Zasowski EJ, Murray KP, Trinh TD, Finch NA, Mynatt RP, Rybak MJ. Association between Initial Vancomycin (VAN) Exposure Profile and Nephrotoxicity (NT) among Hospitalized Patients with Bacteremia. 1st American Society for Microbiology Microbe. Boston, MA. June 2016. [Sun. – 501]. Presenter: Zasowski

Trinh TD,Zasowski EJ, Claeys KC, Langf A, Davis SL, Rybak MJ. Predictors of Multidrug Resistant (MDR) Pseudomonas aeruginosa Nosocomial Pneumonia (PA-NP) in the Intensive Care Unit (ICU). 1st American Society for Microbiology Microbe. Boston, MA. June 2016. [Sat. – 381]. Presenter: Trinh

Finch NA, Murray KP, Zasowski EJ, Mynatt RP, Zhao JJ, Yost R, Pogue JM, Rybak MJ. Impact of Area Under the Curve-Targeted Dosing (AUC-TD) on Vancomycin (VAN)-Associated Nephrotoxicity (VN). 1st American Society for Microbiology Microbe. Boston, MA. June 2016. [Fri. – 518]. Presenter: Finch

Zasowski EJ, Trinh TD, Claeys KC, Casapao AM, Sabagha N, Hallesy J, Rybak MJ. Relationship between Duration of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection and Mortality. 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, NL. Apr. 2016. [P1155]. Presenter: Zasowski

Zasowski EJ, Trinh TD, Claeys KC, Casapao AM, Sabagha N, Rybak MJ. Ceftaroline Fosamil for the Treatment of Methicillin-Resistant Staphylococcus aureus Infective Endocarditis. 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, NL. Apr. 2016. [P0485]. Presenter: Zasowski

Trinh TD, Zasowski EJ, Claeys KC, Casapao AM, Rybak MJ. Impact of vancomycin population analysis profile (PAP) minimum inhibitory concentration (MIC) in high-inoculum methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI). 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, NL. Apr. 2016. [P0477]. Presenter: Trinh

Murray K, Zasowski EJ, Rybak MJ. Vancomycin Exposure Predicts Early Clinical Response in Complicated Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus. 53rd Meeting of the Infectious Diseases Society of America (IDSA). San Diego, CA. Oct. 2015. [800]. Presenter: Murray

Zasowski EJ, Claeys KC, Lagnf AM, Witt JS, Davis SL, Rybak MJ. Linezolid (LZD) versus High-Dose (HD) Daptomycin (DAP) for the Treatment of Vancomycin-Resistant Enterococcus (VRE) Bloodstream Infections (BSI). 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept. 2015. [3051]. Presenter: Zasowski

Zasowski EJ, Claeys KC, Lagnf AM, Witt JS, Rybak MJ. Predictors of Vancomycin-Resistant Enterococci (VRE) among Patients with Community-Onset Enterococcal Bloodstream Infections (EBSI). 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept. 2015. [3073]. Presenter: Zasowski

Zasowski EJ, Claeys KC, Casapao AM, Sabagha N, Klinker KP, Davis SL, Rybak MJ. Ceftaroline Fosamil (CPT) for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI). 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept. 2015. [2207]. Presenter: Zasowski

Zasowski EJ, Claeys KC, Casapao AM, Sabagha N, Klinker KP, Davis SL, Rybak MJ. Ceftaroline Fosamil (CPT) for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Pneumonia (PNA). 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept. 2015. [2220]. Presenter: Zasowski

Zasowski EJ, Anderson H, Tung A, Steppacher R, Brielmaier B, Mieure KD. Antimicrobial Surgical Prophylaxis Practices Before and After Implementation of Multidisciplinary Interventions Related to Antimicrobial Use in Surgical Patients. 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept. 2015. [2235]. Presenter: Zasowski

Claeys KC, Zasowski EJ, Lagnf AM, Davis SL, Rybak MJ. Propensity Matched Analysis of Daptomycin versus Vancomycin for Bloodstream Infections Caused by Methicillin-Resistant Staphylococcus aureus (MRSA). 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept. 2015. [2762]. Presenter: Claeys

Claeys KC, Zasowski EJ, Lagnf AM, Davis SL, Rybak MJ. Practical Application of Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) in the Treatment of Antibacterial Skin and Skin Structure Infection (ABSSSI). 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, CA. Sept.2015. [1828]. Presenter: Claeys

Zasowski E, Lagnf A, Casapao AM, Rybak MJ. Impact of Delayed Antibiotic Therapy on Outcomes of Patients with Hospital-Onset Enterococcal Bacteremia (EB): a Retrospective Cohort Study. 25th European Congress of Clinical Microbiology and Infectious Diseases. Copenhagen, DK. Apr. 2015. [EP163]. Presenter: Zasowski

Zasowski E, Claeys KC, Roberts KD, Levine DP, Davis SL, Rybak MJ. Retrospective Evaluation of Daptomycin (DAP) plus Ceftaroline fosamil (CPT) versus DAP plus Sulfamethoxazole/Trimethoprim (SMX/TMP) for Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI). 25th European Congress of Clinical Microbiology and Infectious Diseases. Copenhagen, DK. Apr. 2015. [P0700]. Presenter: Zasowski

Zasowski E, Butterfield JM, McNutt LA, Cohen J, Cosler L, Gottwald J, Chen WZ, Lodise TP. Relationship between Time to Clinical Response and Outcomes among PORT III and IV Patients (Pts) with Community-Acquired Bacterial Pneumonia (CABP). 51st Meeting of the Infectious Diseases Society of America (IDSA). San Francisco, CA. Oct. 2013. [915]. Presenter: Zasowski

Zasowski E, Cardone KE, Lodise TP, Grabe DW, Merry Z. Pharmacodynamic Profiling of Intraperitoneal Administration of Ceftazidime. American Society of Health Systems Pharmacists (ASHP) Midyear Clinical. Las Vegas, NV. Dec. 2012. [5-274]. Presenter: Zasowski

Invited Presentation

Use of Rapid Diagnostics and Predictive Modeling for MRSA Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) to Optimize Antibiotic Therapy and Cost of Care in the Emergency Department and Observation Unit, Urban Center for Antimicrobial Resistance, Discovery, Education, and Stewardship (UCARDES) Symposium, Wayne State University, Detroit, Michigan.

Awards and Honors

  • IDWeek Trainee Travel Grant
    Infectious Diseases Society of American
    55th Meeting of the Infectious Diseases Society of America
  • Young Scientist Travel Grant
    European Society of Clinical Microbiology and Infectious Diseases
    26th European Congress of Clinical Microbiology and Infectious Diseases
  • Infectious Diseases Fellows Grant Program
    American Society of Microbiology
    53rd Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Trainee Travel Grant
    Making a Difference in Infectious Diseases
    18th Making a Difference in Infectious Diseases Annual Meeting
  • Rho Chi Pharmaceutical Honor Society
    Gamma Gamma Chapter, Albany College of Pharmacy and Health Sciences, Albany, New York

Professional Service and Memberships

  • European Society of Clinical Microbiology and Infectious Diseases
  • Society of Infectious Diseases Pharmacists
  • Infectious Diseases Society of America
  • American Society of Microbiology
  • American College of Clinical Pharmacy
  • American Society of Health Systems Pharmacists

Editorial Appointments

  • Advisory Board, Infectious Diseases and Therapy
  • Reviewer, Open Forum Infectious Diseases
  • Reviewer, Pharmacotherapy