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Profile: Diana Chow

Diana Chow
Diana S-L. Chow, Ph.D., FNAI
Professor of Pharmaceutics
Director, Institute of Drug Education and Research
Department of Pharmacological and Pharmaceutical Sciences
532 Texas Medical Center Campus
Houston, TX 77030
832-842-8308
832-842-8305 (fax)
DChow@uh.edu

Education

B.S. in Pharmacy, National Taiwan University, School of Pharmacy
M.S. in Natural Product Chemistry College of Pharmacy, Ohio State University
Ph.D. (Pharmaceutics), University of British Columbia, Canada

Research Interests

  • Liposomal formulation of 9-nitro-camptothecin and derivatives - Formulation and pharmacokinetic and pharmacodynamic evaluations
  • Microemulsion formulation of highly insoluble drugs, using taxol as model compounds
  • Protection of natural and photo-aging, and skin cancer by derivatives of Tempol, and its mechanisms

Patents

Diethylstilbestrol dosage form and methods of treatment using thereo

USA Patent No. 8,900,634 (Granted on December 2, 2014)

Liposomal formulations of polymaxin B and uses thereof [PCT/US2013/042166; WO2014028087 A1]

European Patent Filing No. 13829139.8-1456 PCT/US2013042166 Pending (Filing date: April 22, 2015)

Liposomal formulations of polymaxin B and uses thereof

USA Patent Filing No. 13/899,753 Pending (Filing date: May 22, 2013)

Parenteral busulfan for treatment of malignant disease.*

USA patent 5,430,057 (granted July 1995)
USA patent 5,559,148 (granted September 1996)
Australia patent 694141 (granted November 1999)

*Product of Busulfex approved by FDA in 1999 (on market in U.S., Canada, Israel, Europe and Asia since 1999; on market in Australia since 2005)

Parenteral and oral formulations of benzimidazoles – Continuation I.

USA Patent No. 9,259,391 (Granted on October 5, 2015; Issued on February 16, 2016)

Parenteral and oral formulations of benzimidazoles – Continuation I-Division of Patent

USA Patent No. 9,259,390 (Granted on October 6, 2015; Issued on February 16, 2016)

Parenteral and oral formulations of benzimidazoles.

USA Patent 7,419,996 (granted September 2008)
International and U.S. patent continuations pending

Courses

  • PHAR 5432 Pharmacokinetics
  • PHAR 5672, Clinical Pharmaceutical Research (rotation)
  • PCOL 6371 Advanced Pharmacology I (on Pharmacokinetics; 2005-13)
  • PCOL 7433 Recent Advances in Pharmaceutical Sciences
  • PCEU 3340 Pharmaceutical Dosage Forms I
  • PCEU 3341 Pharmaceutical Dosage Forms II
  • PCEU 4341 Dispensing Pharmacy
  • PCEU 6341/PCEU 6198, Advanced Pharmacokinetics
  • PCEU 6345/PCEU 6198, Advanced Pharmaceutics II, Drug Delivery
  • PCEU/PCOL 7350 Laboratory Methods in Pharmaceutical Research

Selected Publications

Journal Articles

Zhang D, Chow DS. Clinical Pharmacokinetics of Mycophenolic Acid in Hematopoietic Stem Cell Transplantation Recipients. Eur J Drug Metab Pharmacokinet. 2017 Apr;42(2):183-189. doi: 10.1007/s13318-016-0378-6. Review. PMID: 27677732

Farhan N, Fitzpatrick S, Shim YM, Paige M, Chow DS. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation, J Pharm Biomed Anal, 128:46-52, 2016.

Zhang D, Renbarger JL, Chow DS. Pharmacokinetic Variability of Mycophenolic Acid in Pediatric and Adult Patients With Hematopoietic Stem Cell Transplantation. J Clin Pharmacol. 2016 Nov;56(11):1378-1386. doi: 10.1002/jcph.745. PMID: 27060685

Farhan N, Fitzpatrick S, Shim YM, Paige M, Chow DS. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation. J Pharm Biomed Anal. 2016 Sep 5;128:46-52. doi: 10.1016/j.jpba.2016.05.014. Epub 2016 May 10. PMID: 27232150

Manchandani P, Zhou J, Ledesma KR, Truong LD, Chow DS, Eriksen JL, Tam VH. Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model. Antimicrob Agents Chemother. 2015 Dec 7;60(2):1029-34. doi: 10.1128/AAC.02445-15. Print 2016 Feb. PMID: 26643340

Zhang D, Wu L, Chow DS, Tam VH, Rios DR. Quantitative determination of dopamine in human plasma by a highly sensitive LC-MS/MS assay: Application in preterm neonates. J Pharm Biomed Anal. 2016 Jan 5;117:227-31. doi: 10.1016/j.jpba.2015.09.003. Epub 2015 Sep 5. PMID: 26372947

MG Fehlings, H Nakashima, N Nagoshi, D S-L. Chow, RG Grossman, B Kopjar. Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial, Spinal Cord, 54: 8-15, 2016; 06/2015; DOI:10.1038/sc. 2015.95, 2015.

Abodakpi H, Gohlke J, Chang KT, Chow DS, Tam VH. Analytical and functional determination of polymyxin B protein binding in serum. Antimicrob Agents Chemother. 2015 Nov;59(11):7121-3. doi: 10.1128/AAC.01815-15. Epub 2015 Aug 31. PMID: 26324262

Katrina N. Leyden, Sandra K. Hanneman, Nikhil S. Padhye, Michael S. Smolensky, Duck-Hee Kang, Diana Shu-Lian Chow, Circadian Rhythm Profiles in Porcine ICU Subjects, Chronobiology International, http://www.tandfonline.com/doi/full/10.3109/ 07420528.2015.1059344, 32 (7): 980-993, 2015.

Wu L, Boyd JL, Daniels V, Wang Z, Chow DS, Putcha L. Dose escalation pharmacokinetics of intranasal scopolamine gel formulation. J Clin Pharmacol. 2015 Feb;55(2):195-203. doi: 10.1002/jcph.391. Epub 2014 Dec 5. PMID: 25187210

Zhang D, Rios DR, Tam VH, Chow DS. Development and validation of a highly sensitive LC-MS/MS assay for the quantification of arginine vasopressin in human plasma and urine: Application in preterm neonates and child. J Pharm Biomed Anal. 2014 Oct;99:67-73. doi: 10.1016/j.jpba.2014.07.001. Epub 2014 Jul 10. PMID: 25072843

Weeks PA, Teng Y, Wu L, Sun M, Yang Z, Chow DS. Chemical and physical compatibility of an intravenous solution of epinephrine with calcium chloride. Int J Pharm Compd. 2014 Mar-Apr;18(2):152-8. PMID: 24881119

He J, Abdelraouf K, Ledesma KR, Chow DS, Tam VH. Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model. Int J Antimicrob Agents. 2013 Dec;42(6):559-64. doi: 10.1016/j.ijantimicag.2013.07.009. Epub 2013 Aug 22. PMID: 2401679

Grossman RG, Fehlings M, Frankowski R, Burau KD, Chow D, Tator C, Teng Y, Toups EG, Harrop JS, Aarabi B, Shaffrey C, Johnson MM, Harkema S, Boakye M, Guest J, Wilson JR. A Prospective Multicenter Phase 1 Matched Comparison Group Trial of Safety, Pharmacokinetics, and Preliminary Efficacy of Riluzole in Patients with Traumatic Spinal Cord Injury. J Neurotrauma. 2014 Feb 1;31(3):239-55. doi: 10.1089/neu.2013.2969. Epub 2013 Oct 11. PMID: 2385943

Wu Y, Satkunendrarajah K, Teng Y, Chow DS, Buttigieg J, Fehlings MG. Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury. J Neurotrauma. 2013 Mar 15;30(6):441-52. doi: 10.1089/neu.2012.2622. Epub 2013 Mar 21. PMID: 23517137

He J, Gao S, Hu M, Chow DS, Tam VH. A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. J Antimicrob Chemother. 2013 May;68(5):1104-10. doi: 10.1093/jac/dks536. Epub 2013 Jan 22. PMID: 2334112

Chow DS, Teng Y, Toups EG, Aarabi B, Harrop JS, Shaffrey CI, Johnson MM, Boakye M, Frankowski RF, Fehlings MG, Grossman RG. Pharmacology of riluzole in acute spinal cord injury. J Neurosurg Spine. 2012 Sep;17(1 Suppl):129-40. doi: 10.3171/2012.5.AOSPINE12112. PMID: 22985379

Dong D, Wu B, Chow D, Hu M. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012 May;44(2):192-208. doi: 10.3109/03602532.2011.645580. Epub 2012 Jan 18. Review. PMID: 22251142

Wu Y, Satkundrarajah K, Teng Y, Chow DS, Fehlings MG. Evaluation of the sodium-glutamate blocker riluzole in a preclinical model of ervical spinal cord injury. Evid Based Spine Care J. 2010 Aug;1(2):71-2. doi: 10.1055/s-0030-1267047. PMID: 23637674

He J, Figueroa DA, Lim TP, Chow DS, Tam VH. Stability of polymyxin B sulfate diluted in 0.9% sodium chloride injection and stored at 4 or 25 degrees C. Am J Health Syst Pharm. 2010 Jul 15;67(14):1191-4.

J. He, K.R. Ledesma, W-Y. Lam, D. A. Figueroa, T-P. Lim, D. S-L. Chow, V. H. Tam. Variability of polymaxin B major components in commercial formulations. International Journal of Antimicrobial Agents, 2010 Mar;35(3):308-10.

A. Nornoo, D. Osborne and D. S-L. Chow. Cremophor-free intravenous microemulsions for paclitaxel (I): Formulation, cytotoxicity and hemolysis. International Journal of Pharmaceutics [Impact Factor (IF) 2.408], 10.1016/j.ijpharm.2007.07.042; 349: 108-116, 2008.

A. Nornoo and D. S-L. Chow. Cremophor-free intravenous microemulsions for paclitaxel (II):  Stability, in vitro release and pharmacokinetics. International Journal of Pharmaceutics [IF 2.408], 10.1016/j.ijpharm.2007.07.043; 349: 117-123, 2008.

Book Chapters

S.W. J. Lau, L.K. Cheung and D. S-L. Chow, "Chapter 23 Application of Pharmacokinetics to Specific Populations," in Applied Biopharmaceutics and Pharmacokinetics, 7th Ed, Shargel and Yu (Editors), McGraw Hill, pp. 735-774, 2015.

D. S-L. Chow, L. Gong, M.D. Wolfe and B.C. Giovanella. "Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitrocamptothecin," The Camptothecins: Unfolding Their Anticancer Potential, Annals of The New York Academy of Sciences [IF 1.731], 922: 164-174, 2000. 
 
D. Hsieh, D. Chow  and J. Chen. "Selective Drug Targeting," Controlled Released System: Fabrication Technology, Vol. II, CRC Press, pp.145-162 1988.

Meeting Abstracts and Presentation (since 2010)



Lei Wu, Diana S-L Chow and Vernie Daniels, Development and Validation of anUPLC-MS/MS Method for Simultaneous Determination of Ibuprofen and Promethazine in Tablets Stored on Board the International Space Station. Presented in 30th Annual Meeting of American Association of Pharmaceutical Scientist (AAPS), Denver, CO, November 13-17, 2016.

Daping Zhang*, Lorita Agu*, Anna Carmela P. Sagcal-Gironella, Diana S-L. Chow, Pharmacokinetics of Mycophenolic Acid in Patients with Childhood-Onset Systemic Lupus Erythematosus. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016. [*Sharing first authorship]

Nashid Farhan, Mikell Paige, Yun M Shim, Diana S-L. Chow, In vitro Metabolic Profile of 4-Methoxydiphenylmethane in Rat Liver Microsomes. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016.

Nashid Farhan, Mikell Paige, Yun M Shim, Diana S-L. Chow, Pharmacokinetics and Disposition of 4-Methoxydiphenylmethane in Sprague Dawley Rats. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016.

Asma El-Zailik, Lily K. Cheung, Vadim Sherman, Diana S-L Chow, Metformin Pharmacokinetics and Pharmacodynamics before and after Gastric Bypass Surgery. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016.

Mahua Sarkar, Robert Grossman, Diana S-L Chow, Plasma Pharmacokinetics of Riluzole from Liquid Formulation after Oral and Intravenous Administrations in Rats. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016.

Cheng-Hui Hsiao*, Shuo-Hsiu Chang*, Lorita Agu, Beiyi Zhou, Taimoor Afzal, Diana S-L Chow, Impact of whole body vibration training on BDNF level for rehabilitation in persons with chronic stroke. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016.

Yu Jin Kim, Diana S-L Chow, Characteristics of Biliary Excretions of CZ48 and Its Active Moiety, Camptothecin, after an Oral Administration of CZ48 in Rats. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13-17, 2016.

Mahua Sarkar, Raymond Grill, Robert Grossman and Diana S-L Chow, Impact of Co-administered Minocycline on Plasma Pharmacokinetics and CNS Distribution of Riluzole. Presented at the 45th Annual Meeting of American College of Clinical Pharmacology (ACCP), Washington, DC, September 25-27, 2016. [Mahua Sarkar: Winner of ACCP President’s Student Abstract Award].

Asma El-Zailik, Lily Cheung, Vadim Sherman, Diana S-L. Chow, Impacts of Gastric Bypass Surgery on the Pharmacokinetics and Pharmacodynamics of Simvastatin, Atorvastatin, and Rosuvastatin. Presented at the 45th Annual Meeting of ACCP, Washington, DC, September 25-27, 2016. [Asma El-Zailik: Winner of ACCP President’s Student Abstract Award].

Yu Jin Kim, Yifan Tu, Diana S-L. Chow, Biliary Excretions of CZ48 and Its Active Moiety, Camptothecin, after Intravenous Administration of CZ48 in Rats. Presented at the 45th Annual Meeting of ACCP, Washington, DC, September 25-27, 2016.

Asma El-Zailik, Lily Cheung, Vadim Sherman, Diana S-L. Chow, Effect of Gastric Bypass Surgery on the Pharmacokinetics and Pharmacodynamics of Simvastatin. Presented at 29th Annual Meeting of American Association of Pharmaceutical Scientist (AAPS), Orlando, FL, October 25-29, 2015.

Prajakta Gadgil, Diana S-L. Chow, Pharmacokinetics and Biodistribution with Enhanced Brain Delivery of Radio-Protective Agent Lazaroid Using Lipid Based Nano-formulation. Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Mahua Sarkar, Diana S-L. Chow, Effect of Co-administered Minocycline on Plasma Pharmacokinetics and Brain Distribution of Riluzole in Rats. Effect of Co-administered Minocycline on Plasma Pharmacokinetics and Brain Distribution of Riluzole in Rats. Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Cheng-Hui Hsiao, Zhiyi Cui, Lei Wu, Olutoyin Olutoye, Dong Liang, Diana S-L. Chow, Impact of Fat Percentage on Propofol Pharmacodynamics in Obese Zucker Rat Model. Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Lei Wu, Diana S-L. Chow, Vincent Tam, Lakshmi Putcha, Validation of a Best-Fit Pharmacokinetic Model for Scopolamine Disposition after Intranasal Administration. Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Nashid Farhan, Mikell Paige, Yun Shim, Diana S-L. Chow, Development and Validation of APPI - LC-MS/MS Assay for 4-Methoxydiphenylmethane in Rat Plasma, Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Yu Jin Kim, Diana S-L. Chow, Development of Ultra-Performance Liquid Chromatography and Tandem Mass Spectrometry (UPLC-MS/MS) Assay for Simultaneous Quantifications of CZ48 and Camptothecin in Rat. Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Daping Zhang, Diana S-L. Chow, Jamie L. Renbarger, Variability in Pharmacokinetics of Mycophenolic Acid between Pediatric and Adult Patients with Hematopoietic Stem Cell Transplantation: From Plasma Binding and Metabolic Perspectives. Presented in the 44th Annual Meeting of ACCP, San Francisco, CA, September 27-29, 2015. [Daping Zhang: Winner of ACCP President’s Student Abstract Award].

Lei, Wu, Diana S-L. Chow, Lakshmi Putcha, The utility of the population approach of bioequivalence analysis for intranasal scopolamine in simulated microgravity study. Presented in the 44th Annual Meeting of ACCP, San Francisco, CA, September 27-29, 2015. [Lei Wu: Winner of ACCP President’s Student Abstract Award].

Cheng-Hui Hsiao, Olutoyin Olutoye, David Lazar, Lei Wu, Dong Liang and Diana S-L. Chow, Fat Percentage as Important Covariate on Propofol Pharmacokinetics in Pediatric Obese Population. Presented in the 44th Annual Meeting of ACCP, San Francisco, CA, September 27-29, 2015. [Cheng-Hui Hsiao: Winner of ACCP President’s Student Abstract Award].

Prajakta S. Gadgil, Diana S-L. Chow, Development, Optimization and In-vitro Characterization of Lazaroid Nano-structured Lipid Carriers. Presented in 42ndAnnual Meeting and Exposition of the Controlled Release Society (CRS), Edinburgh, Scotland, July 26-29, 2015.

Prajakta S. Gadgil, Pamela New, Jaymin Shah, Diana S-L. Chow, Lazaroid formulations for brain delivery in treatment of glioblastoma multiforme. Presented in the 106th Annual Meeting of American Association for Cancer Research (AACR), Philadelphia, PA, April 18-22, 2015.

Zhiyi Cui, Olutoyin Olutoye, Z Irving, R Rodrigo, OO Olutoye, Diana S-L. Chow, “UGT metabolism of dexmedetomidine in pregnant ewe”. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Asma El-Zailik, Diana S-L Chow, Lily Cheung, Vadim Sherman, "Effort of undergoing gastric bypass surgery on pharmacokinetics and pharmacodynamics of metformin and statins." Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Lili Cui, M Zhou, C Xiong, Chun Li, Diana S-L Chow, “Integrin 3-targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation (PTA) Therapy”. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Nashid Farhan, Mikell Paige, Yun M Shim, Diana Shu-Lian Chow, “Development, Validation and Application of a UPLC Method for 4-Methoxydiphenylmethane”. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Yu Jin Kim, Dong Dong, Diana Shu-Lian Chow, "Biodistributions of CZ48 and Its Active Metabolite, Camptothecin, in Organs and Tumor of Tumor-Xenografted Mice after Intravenous Administration of Nanosuspension of CZ48". Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Lei, Wu, Vincent Tam, Diana S-L. Chow, Lakshmi Putcha, "A Population Pharmaco-kinetic Model for Disposition in Plasma, Saliva and Urine of Scopolamine after Intranasal Administration to Healthy Human Subjects”. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Daping Zhang, Danielle R. Rios, Diana S-L. Chow, "Development and Validation of a Sensitive Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry (UPLC-MS/MS) for Quantification of Dopamine in Human Plasma: Application in Preterm Neonates". Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Mahua Sarkar, Robert Grossman, Diana S-L. Chow, “Optimization of Liquid Formulation of Riluzole Using Central Composite Design”. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Cheng-Hui Hsiao, Zhiyi Cui, Lei Wu, Olutoyin A. Olutoye, Dong Liang, and Diana S-L. Chow, “Fat Percentage as Important Covariate on Propofol Pharmacokinetics in Obese Zucker Rat Model”. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Lei Wu, Vincent Tam, Diana S-L. Chow, Lakshmi Putcha, “Pharmacokinetic modeling of intranasal scopolamine in plasma saliva and urine”. Presented in the 43rd Annual Meeting of ACCP, Atlanta, GA, September 14-16, 2014 [Lei Wu: Winner of ACCP President’s Student Abstract Award].

Zhiyi Cui, Olutoyin Olutoye, DA Lazar, R Ruano, OO Olutoye, Diana S-L. Chow, “Pharmacokinetic modeling of free and total dexmedetomidine in pregnant ewe and fetus”. Presented in the 43rd Annual Meeting of ACCP, Atlanta, GA, September 14-16, 2014.

Sophia Tsakiri, Christine Domonoske, Lingkun Kong, Joe Alcorn, Diana S-L. Chow, Helen Mintz-Hittner, “Serum concentrations of bevacizumab (Avastin) in premature infants with stage 3+ retinopathy of prematurity treated with intraocular bevacizumab”, Presented in 2014 Joint Meeting of Pediatric Academic Societies (PAS) and Asian Society for Pediatric Research (ASPR), Vancouver, BC, Canada, May 3-6, 2014.

Tanay Samant, Shi-Ming Tu, Nora Navone, Jun Yang and Diana S-L. Chow, “Efficacy of diethylstilbestrol nanosuspension formulation in a MDA PCa 183 xenograft mouse model”, Presented at 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Zhiyi Cui, OA Olutoye, Z Irving, R Rodrigo, OO Olutoye and Diana S-L. Chow, “Differential plasma protein binding of dexmedetomidine in pregnant ewe and fetus”. Presented at 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Lili Cui L, M Zhou, C Xiong, C Li and Diana S-L. Chow, “Integrin 3-targeted [64Cu]CuS nanoparticles for PET/CT Imaging and photothermal ablation (PTA) therapy”. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Lei Wu, Diana S-L. Chow, and L Putcha, “Population pharmacokinetics of intranasal scopolamine”. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Cheng-Hui Hsiao, Zhiyi Cui, Olutoyin A. Olutoye, Dong Liang, and Diana S-L. Chow, “Effect of obesity on propofol pharmacokinetics in Zucker rats”. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Prajakta S Gadgil, P New and Diana S-L. Chow, “Preparation and characterization of Lazaroid U-74389G loaded solid lipid nanoparticles”. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Daping Zhang, Danielle R. Rios, Vincent H. Tam and Diana S-L Chow, “Development and validation of a sensitive ultra-performance liquid chromatography/Tandem mass spectrometry (UPLC-MS/MS) for quantification of arginine vasopressin in human plasma and urine”. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Chia-Wen Lee, Lily Cheung, Vadim Sherman and Diana S-L Chow, “Pharmacokinetics variations of metformin used in patients undergoing gastric bypass surgery”. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Zhiyi Cui, OA Olutoye, Z Irving, R Rodrigo, OO Olutoye and Diana S-L. Chow, “Pharmacokinetics and placental transfer of dexmedetomidine in the pregnant ewe-fetus model”. Presented in the 42nd Annual Meeting of ACCP, Bethesda, MD, September 22-24, 2013 [Zhiyi Cui: Winner of ACCP President’s Student Abstract Award].

Lei Wu, Diana S-L. Chow, and L Putcha, “Impact of gender on pharmacokinetics of intranasal scopolamine”. Presented in the 42nd Annual Meeting of ACCP, Bethesda, MD, September 22-24, 2013.

Cheng-Hui Hsiao, Olutoyin A. Olutoye, David Lazar, Dong Liang, and Diana S-L. Chow, “Pharmacokinetics of propofol in pediatric obese population”. Presented in the 42nd Annual Meeting of ACCP, Bethesda, MD, September 22-24, 2013.

Tanay Samant, Shi-Ming Tu, Jaymin Shah and Diana S-L. Chow, “Development and preclinical PK/PD evaluations of diethylstilbestrol nanosuspensions in rats”. Presented in 40th Annual Meeting and Exposition of the CRS, Honolulu, Hawaii, July 21-24, 2013.

Lili Cui, Ming Zhou, Chiyi Xiong, Chun Li and Diana S-L. Chow, “Development of targeted [64Cu]CuS nanoparticles for PET/CT imaging and photothermal ablation therapy”. Presented in 40th Annual Meeting and Exposition of CRS, Honolulu, Hawaii, July 21-24, 2013.

Dong Dong, Beppino C. Giovanella, Xin Liu, Cheng-Hui Hsiao, Yang Teng, Diana S-L, Chow, “Sustained delivery of CZ48, a lactone-stabilized camptothecin, by nanosuspensions”. Presented in the 104th Annual Meeting of AACR, Washington DC, April 10, 2013.

Cheng-Hui Hsiao, Dong Liang and Diana S-L. Chow, “Pharmacokinetics and pharmacodynamics of propofol in obese Zucker rats”. Presented in 26th Annual Meeting, AAPS, Chicago, IL, October 14-18, 2012.

Zhiyi Cui, Lei Wu, Olutoyin A. Olutoye, Diana S-L. Chow, “Determination of dexmedetomidine in maternal - fetal unit of pregnant ewes using high performance liquid chromatography - tandem mass spectrometric detection”. Presented in 26th Annual Meeting of AAPS, Chicago, IL, October 14-18, 2012.

L Wu , VR Daniels, CJ Crady, D. S-L. Chow and L. Putcha, “Dose-escalating clinical pharmacokinetics of scopolamine in plasma, saliva and urine from intranasal gel formulation”. Presented in 26th Annual Meeting of AAPS, Chicago, IL, October 14-18, 2012.

Tanay Samant, Shi-Ming Tu, Diana S-L. Chow, “Hepatic exposure and pharmacodynamics of diethylstilbestrol nanosuspension in rats”. Presented in 26th Annual Meeting of AAPS, Chicago, IL, October 14-18, 2012.

Dong Dong, Beppino C. Giovanella, and Diana S-L. Chow, “Biodistribution of parenteral nanosuspensions of CZ48, lactone-stabilized prodrug of camptothecin in rats”. Presented in 26th Annual Meeting of AAPS, Chicago, IL, October 14-18, 2012.

Robert Grossman, Michael Fehlings, Ralph Frankowski, Keith Burau, Diana S-L. Chow, Yang Teng, Elizabeth Toups, Jefferson Wilson, James Harrop, Bizhan Aarabi, Christopher Shaffrey, Maxwell Boakye, Susan Harkema, Michele Johnson, James Guest, “A phase I multicenter trial to investigate the safety and pharmacokinetic profile of riluzole in the treatment of traumatic spinal cord injury”, Annual Meeting of Society of Neuroscience, October 13-17, 2012.

Y Teng, D. S-L. Chow, EG Toups, B Aarabi, JS Harrop, CI Shaffrey, MM Johnson, M Boakye, MG Fehlings, RF Frankowski and RG Grossman, “Clinical pharmacokinetics and pharmacodynamics of riluzole in acute spinal cord injured patients”. Presented in the 41st Annual Meeting of ACCP, San Diego, CA, September 23-25, Clinical Pharmacology in Drug Development, 1: 207, 2012.

L Wu , VR Daniels, CJ Crady, D. S-L. Chow and L. Putcha, “Pharmacokinetics of intranasal scopolamine gel formulation – A dose escalation clinical trial”. Presented in the 41st Annual Meeting of ACCP, San Diego, CA, September 23-25, Clinical Pharmacology in Drug Development, 1: 204, 2012 [L Wu: Winner of ACCP President’s Student Abstract Award].

J He, K Abdelraouf, KR Ledesma, D. S-L. Chow, VH Tam. Pulmonary target delivery of polymyxin B for enhanced efficacy. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, California, September 9-12, 2012.

Y. Teng, E. Toups, R. Grossman, Diana S-L. Chow, “Effects of different formulations on riluzole pharmacokinetics”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Dong Dong, Beppino C. Giovanella, and Diana S-L. Chow, “Nanosuspensions of CZ48, lactone-stabilized prodrug of camptothecin- Pharmacokinetics and organ distribution of intravenous administration in rats”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Tanay Samant1, Shi-Ming Tu2 and Diana S-L. Chow, “Pharmacokinetics and pharmacodynamics of diethylstilbestrol nanosuspension in rats”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Lei Wu, V.R. Daniels, C.J. Crady, Diana S-L. Chow and Lakshmi Putcha, “Pharmacokinetics of intranasal scopolamine gel formulation during antiorthostatic bedrest - a microgravity analog”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Cheng-Hui Hsiao, Olutoyin A. Olutoye, Dong Liang, and Diana S-L. Chow, “Pharmacokinetics and pharmacodynamics of propofol in pediatric obese population”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Jui-Chen Tsai, Dong Dong, Hsin-Yi Lai, and Diana S-L. Chow, “Development of curcumin nano/microemulsions for versatile routes of administration”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Jie He, V.H. Tam and Diana S-L. Chow, “Plasma protein binding of polymyxin B major components in three mammalian species”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Zheng Wang, Olson Chu, Roland Ako and Diana S-L. Chow, “Preparation and characterization of NAL1892 diethylstilbestrol orally dissolving film (ODF)”. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

J He, K Abdelraouf, D. S-L. Chow, VH Tam. “Allometric scaling to evaluate the pharmacokinetics of polymyxin B1 among three mammalian species”. ICAAC, Chicago, Illinois, September 17-20, 2011.

Roland Ako, Shi-Ming Tu and Diana S-L. Chow, “Effect of diethylstilbestrol on levels of prostate specific antigen and clotting factor in patients with recurrent prostate cancer”. Presented in the 40thAnnual Meeting of ACCP, Chicago, IL, September 11-13, 2011. [Roland Ako: Winner of ACCP President’s Student Abstract Award]

Diana S-L. Chow, Yang Teng, Elizabeth G. Toups, Bizhan Aarabi, James S. Harrop, Christopher I. Shaffrey, Michele M. Johnson, Maxwell Boakye, Michael G. Fehlings and Robert G. Grossman, “Clinical pharmacokinetics of riluzole in acute spinal cord injured patients”. Presented in the 40thAnnual Meeting of ACCP, Chicago, IL, September 11-13, 2011.

Dong Dong, Beppino C. Giovanella, and Diana S-L Chow, “Optimization and pharmacokinetics of nanoformulation of CZ48, lactone-stabilized prodrug of camptothecin”. Presented in the 38thAnnual Meeting and Exposition of the CRS, Washington, DC, July 30-August 3, 2011.

Tanay Samant and Diana S-L Chow, “Formulation, in vitro release and pharmacokinetics of diethylstilbestrol nanosuspension in rats”. Presented in the 38thAnnual Meeting and Exposition of the CRS, Washington, DC, July 30-August 3, 2011.

Fady Ibrahim, Kemi Cui, Pamela New, Lulu Wang, Hong Zhao, Stephen Wong and Diana S-L. Chow, “Dual Efficacy of Lazaroid U-74389G Liposomes in Glioblastoma Mouse Model”. Presented in the 102nd Annual Meeting of AACR, Orlando, FL, April 6, 2011.

Roland Ako, Shi-Ming Tu and Diana S-L. Chow, "Comparative pharmacokinetics of diethylstilbestrol from oral suspension and oral dissolving film (ODF)." Presented in the 102nd Annual Meeting of AACR, Orlando, FL, April 4, 2011.

Tanay Samant and Diana S-L. Chow, "Development of nanosuspension formulation of diethylstilbestrol and effect of particle size on the in vitro drug release." Presented in the 102nd Annual Meeting of American Association for Cancer Research (AACR), Orlando, FL, April 3, 2011.

Fady Ibrahim, Pamela New and Diana S-L. Chow. “Formulation and Pharmacokinetics of Lazaroid U-74389G (LAZ) Liposomes in Rats”. Presented at the 101st Annual Meeting of American Association for Cancer Research (AACR), Washington, D.C., April 17-21, 2010.

 

 

Invited Lectures and Presentations

Keynote Speaker, Inventor Patent Awards and Celebration of Researchers Luncheon, University of Houston, March 10, 2016.
"Discovering Impactful Drugs in Academia? Same Successful Formula as in Industry: Luck and Perseverance."

University of British Columbia, Vancouver, BC. Canada, September 26, 2014. "Translational Research for Optimizing Therapy Using Approaches of Nanoformulation Development and Pharmacokinetic/Pharmacodynamic Correlation" in Agents of Change Research Symposium – The Global Impact of UBC Pharm Sci Alumni, Inaugural Symposium.

University of Texas Medical School at Houston, Clinical Oncology Working Group, May 3, 2013. "Pharmacokinetics and pharmacodynamics in drug development."

National Taiwan University, College of Medicine, School of Pharmacy, Taipei, Taiwan, June 28, 2012. "Nanoformulations with significant impacts on pharmacokinetics and pharmacodynamics."

Taipei Medical University, Taipei, Taiwan, June 27, 2012. "Nanoformulations with significant impacts on pharmacokinetics and pharmacodynamics" and "Clinical pharmacokinetic and pharmacodynamic correlations of riluzole in patients with traumatic spinal cord injury."

Taiwan FDA, Taipei, Taiwan, June 26, 2012. "Regulatory considerations and challengers for pharmaceutical nanotechnology."

National Cheng Kung University, Medical College, Institute of Clinical Pharmacy and Pharmaceutical Sciences, Tainan, Taiwan, June 25, 2012. "Nanoformulations with significant impacts on pharmacokinetics and pharmacodynamics."

Chinese University of Hong Kong, Faculty of Medicine, School of Pharmacy, Satin, NT, Hong Kong, June 21, 2012. "Nanoformulations with significant impacts on pharmacokinetics and pharmacodynamics."

Zhejiang University, College of Pharmaceutical Sciences, Hangzhou, Zhejiang, China, June 18, 2012. "Nanoformulations with significant impacts on pharmacokinetics and pharmacodynamics."

Ningxia Medical University, Yingchun, Ningxia, China, June 14, 2012. “Clinical pharmacokinetic and pharmacodynamic correlations of riluzole in patients with traumatic spinal cord injury.”

Northeast Forest University, Harbin, China, June 11, 2012. "Sustained delivery of CZ48, lactone-stabilized camptothecin by nanosuspensions."

"Pharmacokinetics and pharmacodynamics of riluzole in patients with acute traumatic spinal cord injury." North American Clinical Trial Network (NACTN) Meeting, Toronto, Ontario, Canada, March 18, 2011.

"Nanoformulations for Cancer Therapy with Significant Impacts on Pharmacokinetics and Pharmacodynamics." University of Toronto, Leslie Dan Faculty of Pharmacy, March 16, 2011.

"Approaches of Nanomedicine Formulations in Cancer Therapy for Achieving Significant Impacts on Pharmacokinetics and Biodistributions." The 6th Annual Congress of International Drug Discovery Science and Technology (IDDST), Beijing, China, October 18-22, 2008.

"Nanomedicine – self-nanoemulsifying drug delivery system (SNEDDS) and nanosuspension for oral and parenteral formulations in cancer therapy with significant impacts on pharmacokinetics and biodistributions." Ehrlich II World Conference on Magic Bullets, (for celebrating 100th Anniversary of Nobel Prize to Paul Ehrlich), Nuremberg, Germany, October 3-5, 2008.

"Approaches of self nanoemulsifying drug delivery system (SNEDDS) and nanosuspension for oral and parenteral formulations in cancer therapy with significant impacts onpharmacokinetics and biodistributions." 2008 Canadian Society of Pharmaceutical Sciences (CSPS) Symposium, Banff, Alberta, Canada, May 22-25, 2008. [unable to attend due to family emergency]

"Pharmacokinetics and pharmacodynamics of riluzole in patients with traumatic spinal cord injury." North American Clinical Trial Network (NACTN) Meeting, Texas Medical Center, Houston, TX, February 18, 2008.

"Pharmacokinetic considerations in drug discovery and development." 2006 ACS-Southwestern Regional Meeting, Symposium on Biopharmaceutical Considerations in Designs of New Drugs,” Houston, TX, October 9-22, 2006.

"Novel drug delivery strategies for optimization of cancer therapy- Collaborations with scientists and clinicians at Texas Medical Center." Silver Anniversary Celebration, College of Pharmacy, University of Houston, at Texas Medical Center, November 11, 2005.

Awards & Honors

  • Honoree, Texas Medical Center Women's History Project, 2017
  • Fellow, National Academy of Inventors, 2016
  • Conversationalist, Top 50 Influential Women in Houston, 19th Annual Table Talk, University of Houston, Women’s, Gender & Sexuality Studies (WGSS) Program, March 24, 2016
  • Keynote Speaker, Inventor Patent Awards and Celebration of Researchers Luncheon, University of Houston, March 10, 2016.
  • Invited Lecturer, Agents of Change Research Symposium: The Global Impact of UBC Pharm Sci Alumni, Sept. 26, 2014, The University of British Columbia Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada
  • Outstanding Alumni Achievement Award, National Taiwan University (NTU), College of Medicine, School of Pharmacy, Taipei, Taiwan, June 28, 2012.
  • Invited Lecturer, National Taiwan University, College of Medicine, School of Pharmacy, Taipei, Taiwan, June 28, 2012.
  • Invited Lecturer, Taipei Medical University, Taipei, Taiwan, June 27, 2012.
  • Invited Lecturer, Taiwan FDA, Taipei, Taiwan, June 26, 2012.
  • Invited Lecturer, National Cheng Kung University, Medical College, Institute of Clinical Pharmacy and Pharmaceutical Sciences, Tainan, Taiwan, June 25, 2012.
  • Invited Lecturer, Chinese University of Hong Kong, Faculty of Medicine, School of Pharmacy, Satin, NT, Hong Kong, June 21, 2012.
  • Invited Lecturer, Zhejiang University, College of Pharmaceutical Sciences, Hangzhou, Zhejiang, China, June 18,2012.
  • Invited Lecturer, Ningxia Medical University, Yingchun, Ningxia, China, June 14, 2012.
  • Invited Lecturer, Northeast Forest University, Harbin, China, June 11, 2012.
  • Invited Lecturer, North American Clinical Trial Network (NACTN) Meeting, March 18, 2011, Toronto, Ontario, Canada
  • 2009 Inventor of the Year Award from the Houston Intellectual Property Law Association (HIPLA) in recognition of patented Parenteral Busulfan for Treatment of Malignant Disease
  • Invited Lecturer and Session Co-Chair on Nanotechnologies and Novel Drug Delivery Technologies, The 6th Annual Congress of International Drug Discovery Science and Technology (IDDST), October 18-22, 2008, Beijing, China.
  • Invited Lecturer, Ehrlich II World Conference on Magic Bullets, (for celebrating 100th Anniversary of Nobel Prize to Paul Ehrlich, October 3, 2008, Nuremberg, Germany.
  • Plenary Lecturer, Canadian Society of Pharmaceutical Sciences (CSPS) Symposium 2008, May 23, 2008. Banff, Alberta, Canada.
  • Invited Lecturer, North American Clinical Trial Network (NACTN) Meeting, February 18, 2008, Texas Medical Center, Houston, TX.
  • Faculty Service Excellence Award, College of Pharmacy, University of Houston, May 2007.
  • 2006 Faculty Scholar Award in Cancer Research, American Association for Cancer Research – Minority-Serving Institution (AACR-MSI), Washington D.C., April 2006.
  • 2005 Faculty Scholar Award in Cancer Research, American Association for Cancer Research – Minority-Serving Institution (AACR-MSI), Anaheim, California, April 2005
  • Invited Lecturer, Ehrlich I World Conference (for celebrating Nobel Laureate Paul Ehrlich’s 150th Birthday), September 9, 2004, Nuremberg, Germany. [Only 1,000 scientists and clinicians were invited from 84 countries.]
  • Gillson Longenbaugh Foundation Research Award, 2003-2008.
  • Plenary Lecturer, Conference on The Camptothecins: Unfolding Their Anticancer Potential, March 18, 2000, Ritz-Carlton Pentagon City, Arlington, Virginia.

Membership and Editorial Appointments

Memberships
  • American Association for Cancer Research, 1995-Present
  • American Association of Clinical Pharmacology, 2011-Present
  • American Association of Pharmaceutical Scientists, 1985-Present
  • Controlled Release Society, 1982-Present
  • American Association of College of Pharmacy, 1982-Present
  • Pharmacy Examining Board of Canada (P.E.B.C. Registrant of Pharmacists), 1979-Present
Editorial Appointments
  • Editor:
    • British Journal of Pharmacology, May 2009 – Present; Reviewer, 2006 – Present
  • Editorial Board Member:
    • Journal of Drug Development and Industrial Pharmacy, 2000-Present
    • International Journal of Pharmaceutics, 1985-Present
    • Journal of Pharmaceutical Sciences, 1988-Present
    • Pharmaceutical Research, 1989-Present
    • European Journal of Pharmaceutics and Biopharmaceutics, 1997-Present
    • International Journal of Pharmaceutical Compounding, 1998-Present
    • Journal of Controlled Release, 2000-Present
    • PDA Journal of Pharmaceutical Science and Technology, 2003-Present
    • Nutrition and Cancer, 2003-Present
    • Journal of Pharmacokinetics and Pharmacodynamics, 2004-Present
    • Toxicology and Applied Pharmacology, 2006-Present
    • Therapeutics and Clinical Risk Management, 2006 – Present
    • Clinical and Experimental Hypertension, 2007-Present
    • J. Chromatograph B, 2008- Present
    • Life Sciences, 2008- Present
    • Molecular Pharmaceutics, 2009- Present
    • Molecular Imaging and Biology, 2010 – Present
    • Journal of Pharmacy and Pharmacology, 2014-Present
    • Clinical Pharmacokinetics, 2014-Present