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MJ, Garrett RH.
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Abstract
  A heretofore undisclosed crux of eosinophilia-myalgia syndrome:
compromised histamine degradation.
Inflamm Res. 2005 Nov;54(11):435-50. Review.
PMID: 16307217 [PubMed - indexed for MEDLINE]

A heretofore undisclosed crux of eosinophilia-myalgia syndrome:
compromised histamine degradation.

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Smith+MJ%22%5BAuthor%5D>Smith
MJ,
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Garrett+RH%22%5BAuthor%5D>Garrett
RH.

Division of Natural Products, Center for Food Safety and Applied
Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway,
College Park, Maryland 20740-3835, USA. mitchell.smith@cfsan.fda.gov

In contrast to early epidemiological evidence offering links between
eosinophilia-myalgia syndrome (EMS) and microimpurities of
L-tryptophan-containing dietary supplements (LTCDS), this account
shows why reliance on a finite impurity from one manufacturer is both
unnecessary and insufficient to explain the etiology of EMS.
Excessive histamine activity has induced blood eosinophilia and
myalgia (Greek: mys, muscle + algos, pain). Termination of the
multiple actions of histamine is dependent on particular amine
oxidases and histamine-N-methyltransferase. Histamine metabolism is
rapid when these degradative reactions are operative. The latent
effects of incurred histamine can be potentiated and aggravating when
these mechanisms are impaired. Overloads of tryptophan supplements
cause - among other relevant side-effects - an increased formation of
formate and indolyl metabolites, several of which inhibit the
degradation of histamine. Moreover, (non-EMS) subjects with
hypothalamic-pituitary- adrenal (HPA) axis dysregulation have also
manifested greatly increased sensitivities to incurred tryptophan and
histamine. A final common pathway for syndromes characterized by
eosinophilia with myalgia is now evident.

Publication Types:
    * Review

PMID: 16307217 [PubMed - indexed for MEDLINE]